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Isoflurane

Name: Isoflurane
Brand: TargetMol
SKU: T19651
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19651Cas No. 26675-46-7

Alias Terrell, HSDB-8057, HSDB8057, HSDB 8057, Forane

Isoflurane (Forane) is a stable, non-explosive inhalation anesthetic that has been reported to induce caspase-3 activation.

Isoflurane

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Catalog No. T19651Alias Terrell, HSDB-8057, HSDB8057, HSDB 8057, ForaneCas No. 26675-46-7

Isoflurane (Forane) is a stable, non-explosive inhalation anesthetic that has been reported to induce caspase-3 activation.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
500 mg	$98	-	In Stock
1 g	$148	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Liquid

Color:Transparent

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COA HNMR

Product Introduction

Isoflurane AI Summary

Isoflurane has a Log BB value of 0.42, indicating its ability to cross the blood-brain barrier and suggesting potential bioactivities in the central nervous system. It exhibits significant anesthetic activity, with a minimum alveolar concentration (MAC) of 1.28 in dogs, 1.15 in humans, and an ED50 of 0.57 in mice, and has a high oil/gas partition coefficient of 97.0. It acts as a potential inhibitor of the Menin-MLL interaction in MLL-related leukemias, with an inhibitory potency of 25118.9 nM. The compound shows bioactivity in inducing liver enzyme activities, including increases in alkaline phosphatase, SGOT, SGPT, LDH, and GGT. It has moderate to high affinities for lung tissues, with in-vitro partition coefficients logP(lung) = 0.0, logK(blood) = 0.2, and logK(lung) = 0.2. Isoflurane exhibits considerable hepatic side effects, scoring high for hepatic failure, hepatic necrosis, hepatitis, and jaundice, resulting in a combined hepatic side effect score of 4.0. It shows moderate hepatotoxicity, with observed acute liver toxicity and severe hepatitis but no chronic liver diseases or tumors. Additionally, it activates human TASK1 channels expressed in COS cells with 25.0% activity at 2 mM compared to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoflurane (Forane) is a stable, non-explosive inhalation anesthetic that has been reported to induce caspase-3 activation.
Synonyms	Terrell, HSDB-8057, HSDB8057, HSDB 8057, Forane

Chemical Properties

Molecular Weight	184.49
Formula	C₃H₂ClF₅O
Cas No.	26675-46-7
Smiles	C(OC(F)F)(C(F)(F)F)Cl
Relative Density.	1.510 g/cm3 at 25℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1355.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4203 mL	27.1017 mL	54.2035 mL	271.0174 mL
5 mM	1.0841 mL	5.4203 mL	10.8407 mL	54.2035 mL
10 mM	0.5420 mL	2.7102 mL	5.4203 mL	27.1017 mL
20 mM	0.2710 mL	1.3551 mL	2.7102 mL	13.5509 mL
50 mM	0.1084 mL	0.5420 mL	1.0841 mL	5.4203 mL
100 mM	0.0542 mL	0.2710 mL	0.5420 mL	2.7102 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc