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AMPK-IN-3

Name: AMPK-IN-3
Brand: TargetMol
SKU: T62745
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62745Cas No. 2417674-27-0

AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.

AMPK-IN-3

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Purity: 97.25%

Catalog No. T62745Cas No. 2417674-27-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$109	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$422	In Stock	In Stock
25 mg	$872	In Stock	In Stock
50 mg	$1,170	In Stock	In Stock
100 mg	$1,580	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.25%

Appearance:Solid

Color:Orange

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.
Targets&IC50	AMPK α2:60.7 nM, KDR:3820 nM, AMPK α1:107 nM
In vitro	At a concentration of 100 nM, AMPK-IN-3 exhibits inhibition values of 64%, 43%, 41%, and 29% for AMPK(α2), FLT1, JAK1 JH2-pseudokinase, and AMPK(α1), respectively[1].In K562 cells, AMPK-IN-3, when applied at concentrations of 0.195313, 0.78125, 3.125, 12.5, and 50 µM for 2 hours, reduces the level of p-ACC[1]. For a duration of 24, 48, and 72 hours, AMPK-IN-3, within the concentration range of 1-100 µM, demonstrates potent inhibition of cellular AMPK activity without affecting cell viability[1].

Chemical Properties

Molecular Weight	451.56
Formula	C₂₅H₃₃N₅O₃
Cas No.	2417674-27-0
Smiles	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC(N)=O)cc23)c1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (110.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2145 mL	11.0727 mL	22.1455 mL	110.7273 mL
5 mM	0.4429 mL	2.2145 mL	4.4291 mL	22.1455 mL
10 mM	0.2215 mL	1.1073 mL	2.2145 mL	11.0727 mL
20 mM	0.1107 mL	0.5536 mL	1.1073 mL	5.5364 mL
50 mM	0.0443 mL	0.2215 mL	0.4429 mL	2.2145 mL
100 mM	0.0221 mL	0.1107 mL	0.2215 mL	1.1073 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc