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Blosozumab (Synonyms: TST-002, TST002, LY-2541546, LY2541546)

Catalog No. T78278 Copy Product Info
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Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.

Blosozumab

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Catalog No. T78278
Synonyms TST-002, TST002, LY-2541546, LY2541546

Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.

Blosozumab
Cas No. 1132758-87-2
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$228-In Stock
5 mg$629-In Stock
10 mg$993-In Stock
25 mg$1,470-In Stock
50 mg$1,980-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.53% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.
In vivo
Blosozumab is a humanized monoclonal antibody (IgG4) that has been optimized for neutralizing the sclerosing protein. In 5 - and 6-month non-clinical safety studies in rats, Blosozumab resulted in a dose-dependent, reversible reduction in platelet counts, accompanied by accelerated platelet production, increased megakaryocyte growth, and altered megakaryocyte morphology. There was no change in platelet counts or megakaryocytes in cynomophagus monkeys treated with Blosozumab. [1]
SynonymsTST-002, TST002, LY-2541546, LY2541546
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetSOST/Sclerostin
Chemical Properties
Molecular Weight144.88 kDa
Cas No.1132758-87-2
Antibody Information
IsotypeHuman IgG4SP kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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