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Blosozumab
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Catalog No. T78278Cas No. 1132758-87-2
Alias TST-002, TST002, LY-2541546, LY2541546
Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.
Blosozumab
Blosozumab
😃Good
Catalog No. T78278Alias TST-002, TST002, LY-2541546, LY2541546Cas No. 1132758-87-2
Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | - | In Stock | |
| 5 mg | $629 | - | In Stock | |
| 10 mg | $993 | - | In Stock | |
| 25 mg | $1,470 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.53% (SEC-HPLC)
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| Description | Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway. |
| In vivo | Blosozumab is a humanized monoclonal antibody (IgG4) that has been optimized for neutralizing the sclerosing protein. In 5 - and 6-month non-clinical safety studies in rats, Blosozumab resulted in a dose-dependent, reversible reduction in platelet counts, accompanied by accelerated platelet production, increased megakaryocyte growth, and altered megakaryocyte morphology. There was no change in platelet counts or megakaryocytes in cynomophagus monkeys treated with Blosozumab. [1] |
| Synonyms | TST-002, TST002, LY-2541546, LY2541546 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | SOST/Sclerostin |
| Molecular Weight | 144.88 kDa |
| Cas No. | 1132758-87-2 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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