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Sphinganine 1-phosphate

Name: Sphinganine 1-phosphate
Brand: TargetMol
SKU: T39401
Rating: 4.5 (1 reviews)

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Catalog No. T39401Cas No. 19794-97-9

Alias Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphate

Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.

Sphinganine 1-phosphate

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Catalog No. T39401Alias Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphateCas No. 19794-97-9

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$223	35 days	35 days
1 mg	$395	35 days	35 days
5 mg	$1,430	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.
In vitro	Sphinganine 1-phosphate (S1P) (1 μM) phosphorylates ERK MAPK, AKT and HSP27 and induces HSP27 in human renal endothelial cells. [2]
In vivo	Methods: Male C57BL/6 mice were treated with Sphinganine 1-phosphate (0.1 mg/kg, 0.1 mg/kg intravenously immediately before reperfusion, 0.2 mg/kg subcutaneously 2 hours after reperfusion) and the changes in plasma levels of alanine aminotransferase (ALT) and creatinine (CR) were analyzed. Results: The plasma levels of alanine aminotransferase (ALT) and creatinine (CR) were 80±6 U/L and 0.46±0.05 mg/dl, respectively; in mice treated with Sphinganine 1-phosphate (0.1 mg/kg), the increase in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) was significantly suppressed after 24 hours. [2]
Synonyms	Sphinganine-1-phosphate (d18:0), D-erythro-Dihydrosphingosine 1-phosphate

Chemical Properties

Molecular Weight	381.49
Formula	C₁₈H₄₀NO₅P
Cas No.	19794-97-9
Smiles	[C@@H]([C@@H](CCCCCCCCCCCCCCC)O)(COP(=O)(O)O)N

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.3 M NaOH: 1 mg/mL (2.62 mM), Sonication is recommended.

Solution Preparation Table

0.3 M NaOH

	1mg	5mg	10mg	50mg
1 mM	2.6213 mL	13.1065 mL	26.2130 mL	131.0650 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc