Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 985.00 | |
50 mg | 6-8 weeks | $ 1,280.00 | |
100 mg | 6-8 weeks | $ 1,990.00 |
Description | SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1]. |
In vitro | SIRT1-IN-2 (compound 3h) administered at concentrations ranging from 0 to 100 μM over 48 hours effectively inhibits the proliferation of several human cancer cell lines, including K562, HCT-116, HepG2, A549, and MCF-7. The compound also demonstrates significantly reduced cytotoxic effects on normal 293T cells and HUVEC. In terms of concentration and incubation specifics, the inhibition of cancer cell line proliferation exhibits IC50 values of 51, 37, 40, 48, and 48 μM for K562, HCT-116, HepG2, A549, and MCF-7 cell lines, respectively. Conversely, the compound shows considerably lower cytotoxicity towards 293T cells and HUVEC, with IC50 values exceeding 100 μM for 293T cells and being 45 μM for HUVEC. |
Molecular Weight | 250.72 |
Formula | C13H15ClN2O |
CAS No. | 2470969-89-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SIRT1-IN-2 2470969-89-0 inhibitor inhibit