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Nystatin

Name: Nystatin
Brand: TargetMol
SKU: T1678
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1678Cas No. 1400-61-9

Alias Stamycin, Nystavescent, Fungicidin

Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.

Nystatin

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Purity: 99.86%

Catalog No. T1678Alias Stamycin, Nystavescent, FungicidinCas No. 1400-61-9

Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$39	In Stock	In Stock
1 g	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.
Targets&IC50	Wuhan strain:62.5 μg/ml, British mutant:125 μg/ml, Fungus:19.6 μg/mL
In vitro	METHODS: Hippocampal neurons were treated with Nystatin (2.5-25 µM) for 30 min and cell morphology was examined. RESULTS: Acute incubation with different concentrations of Nystatin increased the growth cone size of hippocampal neurons. [1] METHODS: CHO cells were treated with Nystatin (100-300 µmol/L) for 10-60 min, and cell viability was measured by MST-1 assay. RESULTS: Cell viability studies after Nystatin application showed significant concentration- and time-dependent effects. At Nystatin concentrations equal to 100 µmol/L, the percentage of viable cells was significantly higher compared to higher concentrations. [2]
In vivo	Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues rather than in normal tissues of tumor-bearing mice, ultimately leading to elevated antiangiogenic and antitumor efficacies of endostatin in vivo[3]. Liposomal Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group[4].
Synonyms	Stamycin, Nystavescent, Fungicidin

Chemical Properties

Molecular Weight	926.1
Formula	C₄₇H₇₅NO₁₇
Cas No.	1400-61-9
Smiles	C[C@H]1O[C@H]([C@H]([C@H]([C@@H]1O)N)O)OC2CC3OC(CC(C3C(O)=O)O)(CC(C(CCC(CC(CC(CC(OC(C(C(C(/C=C/C=C/CC/C=C/C=C/C=C/C=C/2)C)O)C)C)=O)O)O)O)O)O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (269.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.00 mg/mL (5.40 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0798 mL	5.3990 mL	10.7980 mL	53.9898 mL
5 mM	0.2160 mL	1.0798 mL	2.1596 mL	10.7980 mL
10 mM	0.1080 mL	0.5399 mL	1.0798 mL	5.3990 mL
20 mM	0.0540 mL	0.2699 mL	0.5399 mL	2.6995 mL
50 mM	0.0216 mL	0.1080 mL	0.2160 mL	1.0798 mL
100 mM	0.0108 mL	0.0540 mL	0.1080 mL	0.5399 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc