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Verubulin hydrochloride

Name: Verubulin hydrochloride
Brand: TargetMol
SKU: T13298
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13298Cas No. 917369-31-4

Alias MPC-6827 hydrochloride

Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood-brain barrier permeable microtubule-disrupting agent with potent and broad-spectrum cytotoxic activities and significant anticancer efficacy in human MX-1 breast cancer and various mouse xenograft cancer models.

Verubulin hydrochloride

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Purity: 99.77%

Catalog No. T13298Alias MPC-6827 hydrochlorideCas No. 917369-31-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$222	In Stock	In Stock
100 mg	$316	In Stock	In Stock
200 mg	$457	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Verubulin hydrochloride AI Summary

Verubulin hydrochloride shows significant antitumor activity against human A549 cells xenografted in Balb/c mice, achieving a tumor growth inhibition (TGI) of 68.62% at a dose of 2.5 mg/kg administered via intraperitoneal injection every other day for 10 days. However, in terms of toxicity, the maximum tolerated dose (MTD) in mice is 1.0 mg/kg. Additionally, Verubulin hydrochloride exhibits antiviral activity against SARS-CoV-2. It inhibits the cytotoxicity of SARS-CoV-2 in Caco-2 cells and VERO-6 cells, with inhibition percentages of 50.91% and 0.61% at a concentration of 10 µM, respectively, after 48 hours. The compound also demonstrates bioactivity against the SARS-CoV-2 3CL-Pro protease, showing 12.51% inhibition at 20 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood-brain barrier permeable microtubule-disrupting agent with potent and broad-spectrum cytotoxic activities and significant anticancer efficacy in human MX-1 breast cancer and various mouse xenograft cancer models.
Synonyms	MPC-6827 hydrochloride

Chemical Properties

Molecular Weight	315.8
Formula	C₁₇H₁₈ClN₃O
Cas No.	917369-31-4
Smiles	Cl.COc1ccc(cc1)N(C)c1nc(C)nc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (71.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1666 mL	15.8328 mL	31.6656 mL	158.3281 mL
5 mM	0.6333 mL	3.1666 mL	6.3331 mL	31.6656 mL
10 mM	0.3167 mL	1.5833 mL	3.1666 mL	15.8328 mL
20 mM	0.1583 mL	0.7916 mL	1.5833 mL	7.9164 mL
50 mM	0.0633 mL	0.3167 mL	0.6333 mL	3.1666 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc