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RTC13

Name: RTC13
Brand: TargetMol
SKU: T34425
Rating: 4.5 (1 reviews)

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Catalog No. T34425Cas No. 1359825-94-7

RTC13 is a read-through reagent that restores anti-myasthenia gravis protein expression in the mdx mouse model of Duchenne muscular dystrophy (DMD).

RTC13

🥰Excellent

Catalog No. T34425Cas No. 1359825-94-7

RTC13 is a read-through reagent that restores anti-myasthenia gravis protein expression in the mdx mouse model of Duchenne muscular dystrophy (DMD).

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Product Introduction

Bioactivity

Description	RTC13 is a read-through reagent that restores anti-myasthenia gravis protein expression in the mdx mouse model of Duchenne muscular dystrophy (DMD).
In vivo	Wild-type (C57BL/10) mice received intraperitoneal injections of RTC13 at different doses of 10, 30, 60, and 300 mg/kg.During autopsy, no significant changes in the weights of the liver and kidneys were observed. In addition, histological examination by hemoglobin and eosin (H&E) staining showed no histopathological changes in these organs. [1]

Chemical Properties

Molecular Weight	315.3
Formula	C₁₄H₉N₃O₄S
Cas No.	1359825-94-7
Smiles	O=[N+](C1=C(C=CC=C1)C2=CC=C(/C=C3C(N=C(S/3)N)=O)O2)[O-]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (253.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1716 mL	15.8579 mL	31.7158 mL	158.5791 mL
5 mM	0.6343 mL	3.1716 mL	6.3432 mL	31.7158 mL
10 mM	0.3172 mL	1.5858 mL	3.1716 mL	15.8579 mL
20 mM	0.1586 mL	0.7929 mL	1.5858 mL	7.9290 mL
50 mM	0.0634 mL	0.3172 mL	0.6343 mL	3.1716 mL
100 mM	0.0317 mL	0.1586 mL	0.3172 mL	1.5858 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RTC13