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Quinine

Name: Quinine
Brand: TargetMol
SKU: T0690
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0690Cas No. 130-95-0

Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.

Quinine

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Purity: 99.97%

Catalog No. T0690Cas No. 130-95-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	-	In Stock
5 g	$63	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Color:White

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Product Introduction

Quinine AI Summary

Quinine exhibits potent antimalarial activity against various Plasmodium falciparum strains, including chloroquine-sensitive and chloroquine-resistant types, with IC50 values ranging from 0.019 nM to 0.268 µg/mL. It also shows in vitro cytotoxicity against mouse mammary tumor FM3A cells with an EC50 of 100,000 nM, demonstrating selective toxicity, evidenced by a high therapeutic index against malaria parasites. The compound binds moderately to human serum albumin with a binding percentage of 34.6% at 80 µM and an affinity constant Log K' = 0.49. Additionally, Quinine has inhibitory activity against human liver enzymes such as CYP2D6 and displays genotoxicity at higher concentrations. It also interacts with various cellular transport mechanisms and receptors. These properties highlight its potential as a selective and effective antimalarial agent, with additional pharmacological activities that merit further investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
Targets&IC50	K+ channel:169 μM

Chemical Properties

Molecular Weight	324.42
Formula	C₂₀H₂₄N₂O₂
Cas No.	130-95-0
Smiles	[H][C@@]12CCN(C[C@@H]1C=C)[C@@H](C2)[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1
Relative Density.	>= 110 - <= 140 kg/m3.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (385.3 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0824 mL	15.4121 mL	30.8242 mL	154.1212 mL
5 mM	0.6165 mL	3.0824 mL	6.1648 mL	30.8242 mL
10 mM	0.3082 mL	1.5412 mL	3.0824 mL	15.4121 mL
20 mM	0.1541 mL	0.7706 mL	1.5412 mL	7.7061 mL
50 mM	0.0616 mL	0.3082 mL	0.6165 mL	3.0824 mL
100 mM	0.0308 mL	0.1541 mL	0.3082 mL	1.5412 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc