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Euquinine

Name: Euquinine
Brand: TargetMol
SKU: T0519
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0519Cas No. 83-75-0

Alias Quinine ethylcarbonate

Euquinine (Quinine ethylcarbonate) generally is served as the febrifuge, antimalarial, and tonic.

Euquinine

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Purity: 99.83%

Catalog No. T0519Alias Quinine ethylcarbonateCas No. 83-75-0

Euquinine (Quinine ethylcarbonate) generally is served as the febrifuge, antimalarial, and tonic.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$52	In Stock	In Stock
100 mg	$72	In Stock	In Stock
200 mg	$130	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Color:White

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COA HNMR LCMS

Product Introduction

Euquinine AI Summary

Euquinine inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at 10 μM, with inhibition rates of 58.74% and 64.19%, respectively. It demonstrates bioactivity as an inhibitor against Marburg Virus with a potency of 19952.6 nM and exhibits gametocytocidal activity with a potency of 15848.9 nM. The compound shows some level of activity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.6435. Additionally, it averts SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 42.85% at 10 μM after 48 hours. Although it displays antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and Vero cells with hit scores of 0.1872 and 0.1489, respectively, these scores are below the typical threshold for a hit. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 5.07% at 20 μM. However, it only minimally affects SARS-CoV-2-induced cytotoxicity in VERO-6 cells with an inhibition rate of -0.01% after 48 hours. In human HDAC6 assays, it shows a 14.49% inhibition rate with a commercial peptide substrate but a decrease in inhibition with a custom peptide substrate, exhibiting a rate of -0.15%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Euquinine (Quinine ethylcarbonate) generally is served as the febrifuge, antimalarial, and tonic.
Synonyms	Quinine ethylcarbonate

Chemical Properties

Molecular Weight	396.48
Formula	C₂₃H₂₈N₂O₄
Cas No.	83-75-0
Smiles	[C@H](OC(OCC)=O)([C@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(C=CC(OC)=C4)N=CC3
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (113.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5222 mL	12.6110 mL	25.2220 mL	126.1098 mL
5 mM	0.5044 mL	2.5222 mL	5.0444 mL	25.2220 mL
10 mM	0.2522 mL	1.2611 mL	2.5222 mL	12.6110 mL
20 mM	0.1261 mL	0.6305 mL	1.2611 mL	6.3055 mL
50 mM	0.0504 mL	0.2522 mL	0.5044 mL	2.5222 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc