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Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153)
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Catalog No. TMAY-01426
Alias PHAS-I, BP-1, 4E-BP1, 4EBP1
Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) is a Rabbit antibody targeting Phospho-4E-BP1 (Thr37, 46). Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) can be used in WB.
Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153)
Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153)
😃Good
Catalog No. TMAY-01426Alias PHAS-I, BP-1, 4E-BP1, 4EBP1
Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) is a Rabbit antibody targeting Phospho-4E-BP1 (Thr37, 46). Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $80 | 7-10 days | |
| 100 μL | $235 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) is a Rabbit antibody targeting Phospho-4E-BP1 (Thr37, 46). Anti-Phospho-4E-BP1 (Thr37, 46) Antibody (7K153) can be used in WB. |
| Alias | PHAS-I, BP-1, 4E-BP1, 4EBP1 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7K153 |
| Reactivity | Human;
Species predicted to react based on 100% sequence homology: Mouse, rat |
| Verified Activity | 1. Western blot analysis of extracts from serum-starved HEK293, untreated (line A); treated with IGF1 (100ng/ml, 15min；+) (line B); treated with IGF1 and λ-phosphatase (line C) using Phospho-4E-BP1 (Thr37, 46) rabbit monoclonal Antibody at 1:5000 dilution. (Validation Experiment) 2. Western blot analysis of extracts from HEK293, untreated(line A) or treated with IGF1 (100ng/ml, 15min; +)(line B), using Phospho-4E-BP1 (Thr37, 46) rabbit monoclonal Antibody at 1:5000 dilution (upper) or Anti-4E-BP1 Antibody, Mouse Monoclonal at 1:5000 dilution (lower). |
| Application | WB |
| Recommended Dose | WB: 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to residues around (Thr37, 46) of Human Phospho-4E-BP1. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. Binding of eIF4E to eIF4G is inhibited in a competitive manner by 4E-BP1. Phosphorylation of 4E-BP1 decreases the affinity of this protein for eIF4E, thus favouring the binding of eIF4G and enhancing translation. 4E-BP1 is important for beta-cell survival under endoplasmic reticulum (ER) stress. 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recently, 4E-BP1 was found to be a key factor, which converges several oncogenic signals, phosphorylates the molecules, and drives the downstream proliferative signals. Recent studies showed that high expression of phosphorylated 4E-BP-1 (p-4E-BP1) is associated with poor prognosis, tumor progression, or nodal metastasis in different human cancers. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to residues around (Thr37, 46) of Human Phospho-4E-BP1 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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