Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody

Name: Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01502
Rating: 4.5 (1 reviews)

(Synonyms: SMAD7 (p-Ser249), SMAD7 (p-S249), SMAD7, SMAD, mothers against DPP homolog 7(Drosophila), SMAD, mothers against DPP homolog 7, SMAD family member 7, SMAD 7, SMAD, SMA-AND MAD-RELATED PROTEIN 7, p-SMAD7 (Ser249), p-SMAD7 (S249), Mothers against DPP homolog 8, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, Mothers against decapentaplegic homolog 7, Mothers Against Decapentaplegic Drosophila Homolog of 7, MADH8, MADH 8, MADH 7, MAD(mothers against decapentaplegic Drosophila) homolog 7, MAD mothers against decapentaplegic homolog 7, Mad homolog 7, MAD) Copy Product Info

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Synonyms: SMAD7 (p-Ser249), SMAD7 (p-S249), SMAD7, SMAD, mothers against DPP homolog 7(Drosophila), SMAD, mothers against DPP homolog 7, SMAD family member 7, SMAD 7, SMAD, SMA-AND MAD-RELATED PROTEIN 7, p-SMAD7 (Ser249), p-SMAD7 (S249), Mothers against DPP homolog 8, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, Mothers against decapentaplegic homolog 7, Mothers Against Decapentaplegic Drosophila Homolog of 7, MADH8, MADH 8, MADH 7, MAD(mothers against decapentaplegic Drosophila) homolog 7, MAD mothers against decapentaplegic homolog 7, Mad homolog 7, MAD

Catalog No. TMAB-01502 Copy Product Info

🥰Excellent

Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SMAD7 (Ser249). Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-Phospho-SMAD7
(Ser249) Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SMAD7 (Ser249). Anti-Phospho-SMAD7 (Ser249) Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	SMAD7 (p-Ser249), SMAD7 (p-S249), SMAD7, SMAD, mothers against DPP homolog 7(Drosophila), SMAD, mothers against DPP homolog 7, SMAD family member 7, SMAD 7, SMAD, SMA-AND MAD-RELATED PROTEIN 7, p-SMAD7 (Ser249), p-SMAD7 (S249), Mothers against DPP homolog 8, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, Mothers against decapentaplegic homolog 7, Mothers Against Decapentaplegic Drosophila Homolog of 7, MADH8, MADH 8, MADH 7, MAD(mothers against decapentaplegic Drosophila) homolog 7, MAD mothers against decapentaplegic homolog 7, Mad homolog 7, MAD
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Pig,Cow,GuineaPig)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
Tissue Specificity	Ubiquitous with higher expression in the lung and vascular endothelium.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Antigen Details

Immunogen	KLH conjugated synthesised phosphopeptide: human SMAD7 around the phosphorylation site of Ser249
Antigen Species	Human
Gene Name	SMAD7
Gene ID	4092
Protein Name	Mothers against decapentaplegic homolog 7
Uniprot ID	O15105
Biology Area	SMADs,SMADs
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.