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Anti-AXL Antibody (4J472)
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Catalog No. TMAY-00551
Alias AXL receptor tyrosine kinase
Anti-AXL Antibody (4J472) is a Mouse antibody targeting AXL. Anti-AXL Antibody (4J472) can be used in ELISA.
Anti-AXL Antibody (4J472)
Anti-AXL Antibody (4J472)
😃Good
Catalog No. TMAY-00551Alias AXL receptor tyrosine kinase
Anti-AXL Antibody (4J472) is a Mouse antibody targeting AXL. Anti-AXL Antibody (4J472) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-AXL Antibody (4J472) is a Mouse antibody targeting AXL. Anti-AXL Antibody (4J472) can be used in ELISA. |
| Alias | AXL receptor tyrosine kinase |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4J472 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AXL (rh AXL; TMPY-01601; AAB20305.1; Met 1-Pro 449). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human AXL protein (TMPY-01601) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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