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EP1013

Name: EP1013
Brand: TargetMol
SKU: T11210
Rating: 4.5 (1 reviews)

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Catalog No. T11210Cas No. 223568-55-6

Alias F1013

EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.

EP1013

😃Good

Catalog No. T11210Alias F1013Cas No. 223568-55-6

EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$759	8-10 weeks	8-10 weeks
50 mg	$986	8-10 weeks	8-10 weeks
100 mg	$1,590	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
In vivo	EP1013 therapy significantly improves the functionality and longevity of syngeneic islet grafts by enhancing the islet mass's performance. Administering EP1013 at dosages of 1, 3, and 10 mg/kg results in noticeable improvements in the function of marginal islet mass. Despite two cases of primary islet graft nonfunction in the 10 mg/kg EP1013 treatment group, the overall rate of diabetes reversal among this group does not significantly differ from those treated with 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD.
Synonyms	F1013

Chemical Properties

Molecular Weight	382.38
Formula	C₁₈H₂₃FN₂O₆
Cas No.	223568-55-6
Smiles	[C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@H](C)C)=O)(C(CF)=O)CC(O)=O
Relative Density.	1.258 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (156.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6152 mL	13.0760 mL	26.1520 mL	130.7600 mL
5 mM	0.5230 mL	2.6152 mL	5.2304 mL	26.1520 mL
10 mM	0.2615 mL	1.3076 mL	2.6152 mL	13.0760 mL
20 mM	0.1308 mL	0.6538 mL	1.3076 mL	6.5380 mL
50 mM	0.0523 mL	0.2615 mL	0.5230 mL	2.6152 mL
100 mM	0.0262 mL	0.1308 mL	0.2615 mL	1.3076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc