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Integrin Antagonists 27

Name: Integrin Antagonists 27
Brand: TargetMol
SKU: T15584
Rating: 4.5 (1 reviews)

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Catalog No. T15584Cas No. 593274-97-6

Integrin Antagonists 27, a small molecule integrin αvβ3 antagonist with a binding affinity of 18 nM, serves as a novel anticancer agent.

Integrin Antagonists 27

😃Good

Catalog No. T15584Cas No. 593274-97-6

Integrin Antagonists 27, a small molecule integrin αvβ3 antagonist with a binding affinity of 18 nM, serves as a novel anticancer agent.

Pack Size	Price	Availability
2 mg	$198	8-10 weeks
5 mg	$347	8-10 weeks
25 mg	$1,140	8-10 weeks
50 mg	$1,490	8-10 weeks
100 mg	$1,990	8-10 weeks
1 mL x 10 mM (in DMSO)	$382	8-10 weeks

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Product Introduction

Bioactivity

Description	Integrin Antagonists 27, a small molecule integrin αvβ3 antagonist with a binding affinity of 18 nM, serves as a novel anticancer agent.
In vitro	Integrin Antagonists 27 is treated with a panel of cancer cell lines. Which include breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975. It has an IC50 of >20 uM.

Chemical Properties

Molecular Weight	444.44
Formula	C₂₄H₂₀N₄O₅
Cas No.	593274-97-6
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (225 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2500 mL	11.2501 mL	22.5002 mL	112.5011 mL
5 mM	0.4500 mL	2.2500 mL	4.5000 mL	22.5002 mL
10 mM	0.2250 mL	1.1250 mL	2.2500 mL	11.2501 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6251 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2500 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc