Dot1L-IN-5

Name: Dot1L-IN-5
Brand: TargetMol
SKU: T11084
Rating: 4.5 (1 reviews)

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Catalog No. T11084Cas No. 2565705-03-3

Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].

Dot1L-IN-5

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Catalog No. T11084Cas No. 2565705-03-3

Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].

Pack Size	Price	Availability
25 mg	$1,218	6-8 weeks
50 mg	$1,985	6-8 weeks
100 mg	$2,997	6-8 weeks

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].
Targets&IC50	DOT1L:0.17 nM
In vitro	Dot1L-IN-5 (Compound 11) was evaluated through cellular assays for its efficacy in inhibiting H3K79 dimethylation in HeLa cells (ED 50 H3K79me2 Elisa = 2.9 nM) and suppressing HOXA9 gene expression in Molm-13 cells (ED 50 HOXA9 RGA = 30 nM) [1].
In vivo	Dot1L-IN-5 (Compound 11), administered subcutaneously at a dosage of 75 mg/kg once daily for 20 days to NOD-SCID mice harboring MV4-11 tumor xenografts, failed to inhibit tumor growth. Conversely, administering the same compound twice daily for the same duration resulted in a significant 73% inhibition of tumor growth. Both administration schedules markedly reduced the global H3K79 dimethylation level in the tumor; however, the twice-daily regimen was notably more effective in decreasing the mRNA expression of the target genes HOXA9 and MEIS1.

Chemical Properties

Molecular Weight	592.96
Formula	C₂₃H₁₉ClF₂N₈O₅S
Cas No.	2565705-03-3
Relative Density.	no data available

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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