Shopping Cart

Remove All
Your shopping cart is currently empty

2-Ketoglutaric acid

Name: 2-Ketoglutaric acid
Brand: TargetMol
SKU: T5980
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5980Cas No. 328-50-7

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.

2-Ketoglutaric acid

🥰Excellent

Purity: 99.28%

Catalog No. T5980Cas No. 328-50-7

Pack Size	Price	Availability	Quantity
1 g	$42	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.28%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.
Targets&IC50	HEK293 cells:54 μM (EC50), Tyrosinase:15 mM

Chemical Properties

Molecular Weight	146.1
Formula	C₅H₆O₅
Cas No.	328-50-7
Smiles	OC(=O)CCC(=O)C(O)=O
Relative Density.	1.2821 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 480 mg/mL (3285.42 mM), Sonication is recommended.

H2O: 50 mg/mL (342.23 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8446 mL	34.2231 mL	68.4463 mL	342.2313 mL
5 mM	1.3689 mL	6.8446 mL	13.6893 mL	68.4463 mL
10 mM	0.6845 mL	3.4223 mL	6.8446 mL	34.2231 mL
20 mM	0.3422 mL	1.7112 mL	3.4223 mL	17.1116 mL
50 mM	0.1369 mL	0.6845 mL	1.3689 mL	6.8446 mL
100 mM	0.0684 mL	0.3422 mL	0.6845 mL	3.4223 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc