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2-Ketoglutaric acid

Name: 2-Ketoglutaric acid
Brand: TargetMol
SKU: T5980
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5980Cas No. 328-50-7

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.

2-Ketoglutaric acid

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Purity: 99.28%

Catalog No. T5980Cas No. 328-50-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$42	In Stock	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.28%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.
Targets&IC50	HEK293 cells:54 μM (EC50), Tyrosinase:15 mM

Chemical Properties

Molecular Weight	146.10
Formula	C₅H₆O₅
Cas No.	328-50-7
Smiles	OC(=O)CCC(=O)C(O)=O
Relative Density.	1.2821 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 480.00 mg/mL (3285.42 mM), Sonication is recommended.

H2O: 100 mg/mL (684.46 mM), Sonication is recommended.

In Vivo Formulation

PBS: 100.00 mg/mL (684.46 mM)

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.00 mg/mL (34.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8446 mL	34.2231 mL	68.4463 mL	342.2313 mL
5 mM	1.3689 mL	6.8446 mL	13.6893 mL	68.4463 mL
10 mM	0.6845 mL	3.4223 mL	6.8446 mL	34.2231 mL
20 mM	0.3422 mL	1.7112 mL	3.4223 mL	17.1116 mL
50 mM	0.1369 mL	0.6845 mL	1.3689 mL	6.8446 mL
100 mM	0.0684 mL	0.3422 mL	0.6845 mL	3.4223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc