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SCH79797

Name: SCH79797
Brand: TargetMol
SKU: T28734
Rating: 4.5 (1 reviews)

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Catalog No. T28734Cas No. 245520-69-8

Alias SCH-79797, SCH 79797

SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonist with an IC50=70 nM with antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects that attenuates thrombin-induced increase in CH25H expression in astrocytes, inhibits peritoneal dissemination of gastric cancer, and attenuates repetitive traumatic brain injury.

SCH79797

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Purity: 99.80%

Catalog No. T28734Alias SCH-79797, SCH 79797Cas No. 245520-69-8

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Purity:99.80%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonist with an IC50=70 nM with antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects that attenuates thrombin-induced increase in CH25H expression in astrocytes, inhibits peritoneal dissemination of gastric cancer, and attenuates repetitive traumatic brain injury.
Targets&IC50	PAR1:70 nM, PAR1:35 nM ( ki)
In vivo	Methods: SCH79797 (2.5, 10, 25, 50, 100 and 250 μg/kg, intravenously) was administered to rats and subjected to 30 min of ischemia and 180 min of reperfusion to investigate its cardioprotective effects in vivo. Results: Infarct size, expressed as a percentage of area at risk (AAR), was 62 ± 3 % of the AAR in the control group; no significant changes in infarct size were observed at the lowest (2.5 μg/kg) and highest (250 μg/kg) doses of SCH79797; however, a gradual decrease was observed at doses of 10-100 μg/kg, with 25 μg/kg being the most effective dose. [1]
Synonyms	SCH-79797, SCH 79797

Chemical Properties

Molecular Weight	371.48
Formula	C₂₃H₂₅N₅
Cas No.	245520-69-8
Smiles	N=1C(=NC2=CC=C3C(C=CN3CC4=CC=C(C=C4)C(C)C)=C2C1N)NC5CC5
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (107.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6919 mL	13.4597 mL	26.9193 mL	134.5967 mL
5 mM	0.5384 mL	2.6919 mL	5.3839 mL	26.9193 mL
10 mM	0.2692 mL	1.3460 mL	2.6919 mL	13.4597 mL
20 mM	0.1346 mL	0.6730 mL	1.3460 mL	6.7298 mL
50 mM	0.0538 mL	0.2692 mL	0.5384 mL	2.6919 mL
100 mM	0.0269 mL	0.1346 mL	0.2692 mL	1.3460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc