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CK1-IN-2

Name: CK1-IN-2
Brand: TargetMol
SKU: T79145
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79145Cas No. 1383376-92-8

CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.

CK1-IN-2

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Purity: 99.31%

Catalog No. T79145Cas No. 1383376-92-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$166	-	In Stock
10 mg	$269	-	In Stock
25 mg	$397	-	In Stock
50 mg	$569	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
Targets&IC50	CKIα:123 nM, CK1a:19.8 nM, CK1e:74.3 nM, CK1d:26.8 nM
In vitro	CK1-IN-2 (compound No. 4) is a potent inhibitor of casein kinase 1 (CK1), with IC₅₀ values of 123 nM (CK1α), 19.8 nM (CK1a), 26.8 nM (CK1d), and 74.3 nM (CK1e), indicating subtype selectivity[1]. CK1-IN-2 (0.02-10 μM, 72 h) promotes myotube formation in FSHD (facioscapulohumeral muscular dystrophy) cells, indicating its role in enhancing muscle cell fusion[1]. At 10 μM (72 h), CK1-IN-2 is also capable of reversing the inhibitory effect of Losmapimod on myotube formation[1].

Chemical Properties

Molecular Weight	309.29
Formula	C₁₇H₁₂FN₃O₂
Cas No.	1383376-92-8
Smiles	O=C1OCC2=NC=CC(C3=CN(N=C3C=4C=CC(F)=CC4)C)=C12

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (129.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2332 mL	16.1661 mL	32.3321 mL	161.6606 mL
5 mM	0.6466 mL	3.2332 mL	6.4664 mL	32.3321 mL
10 mM	0.3233 mL	1.6166 mL	3.2332 mL	16.1661 mL
20 mM	0.1617 mL	0.8083 mL	1.6166 mL	8.0830 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2332 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6166 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc