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CK1-IN-2
🥰Excellent
Catalog No. T79145Cas No. 1383376-92-8
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
CK1-IN-2
🥰Excellent
Purity: 99.31%
Catalog No. T79145Cas No. 1383376-92-8
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $166 | In Stock | |
| 10 mg | $269 | In Stock | |
| 25 mg | $397 | In Stock | |
| 50 mg | $569 | In Stock |
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Purity:99.31%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy. |
| Targets&IC50 | CK1e:74.3 nM, CKIα:123 nM, CK1a:19.8 nM, CK1d:26.8 nM |
| In vitro | CK1-IN-2 (compound No. 4) is a potent inhibitor of casein kinase 1 (CK1), with IC₅₀ values of 123 nM (CK1α), 19.8 nM (CK1a), 26.8 nM (CK1d), and 74.3 nM (CK1e), indicating subtype selectivity[1]. CK1-IN-2 (0.02-10 μM, 72 h) promotes myotube formation in FSHD (facioscapulohumeral muscular dystrophy) cells, indicating its role in enhancing muscle cell fusion[1]. At 10 μM (72 h), CK1-IN-2 is also capable of reversing the inhibitory effect of Losmapimod on myotube formation[1]. |
| Molecular Weight | 309.29 |
| Formula | C17H12FN3O2 |
| Cas No. | 1383376-92-8 |
| Smiles | O=C1OCC2=NC=CC(C3=CN(N=C3C=4C=CC(F)=CC4)C)=C12 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (129.33 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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