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CK1-IN-2

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Catalog No. T79145Cas No. 1383376-92-8

CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.

CK1-IN-2

CK1-IN-2

🥰Excellent
Purity: 99.31%
Catalog No. T79145Cas No. 1383376-92-8
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
Pack SizePriceAvailabilityQuantity
1 mg$158 In Stock
5 mg$392 In Stock
10 mg$639 In Stock
25 mg$1,280 In Stock
50 mg$1,980 In Stock
100 mg$3,270 In Stock
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Purity:99.31%
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Product Introduction

Bioactivity
Description
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
Targets&IC50
CK1e:74.3 nM, CK1a:19.8 nM, CK1d:26.8 nM, CKIα:123 nM
In vitro
CK1-IN-2 (compound No. 4) is a potent inhibitor of casein kinase 1 (CK1), with IC₅₀ values of 123 nM (CK1α), 19.8 nM (CK1a), 26.8 nM (CK1d), and 74.3 nM (CK1e), indicating subtype selectivity[1]. CK1-IN-2 (0.02-10 μM, 72 h) promotes myotube formation in FSHD (facioscapulohumeral muscular dystrophy) cells, indicating its role in enhancing muscle cell fusion[1]. At 10 μM (72 h), CK1-IN-2 is also capable of reversing the inhibitory effect of Losmapimod on myotube formation[1].
Chemical Properties
Molecular Weight309.29
FormulaC17H12FN3O2
Cas No.1383376-92-8
SmilesO=C1OCC2=NC=CC(C3=CN(N=C3C=4C=CC(F)=CC4)C)=C12
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (129.33 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2332 mL16.1661 mL32.3321 mL161.6606 mL
5 mM0.6466 mL3.2332 mL6.4664 mL32.3321 mL
10 mM0.3233 mL1.6166 mL3.2332 mL16.1661 mL
20 mM0.1617 mL0.8083 mL1.6166 mL8.0830 mL
50 mM0.0647 mL0.3233 mL0.6466 mL3.2332 mL
100 mM0.0323 mL0.1617 mL0.3233 mL1.6166 mL

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