Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and <100 μM (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 μM. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 116.00 | |
25 mg | In stock | $ 212.00 | |
50 mg | In stock | $ 319.00 | |
100 mg | In stock | $ 475.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 μM. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 μM. |
Targets&IC50 | Skeletal muscle myosin:rabbit, Smooth muscle myosin II:>100 μM, Cardiac muscle myosin:4.4 μM |
In vitro |
N-acetyl-D-Lactosamine (10 microg/ml) was a potent mitogen towards human peripheral blood mononuclear cells.[3] N-acetyl-D-Lactosamine (100 microg/ml) has 50% growth inhibitory potential towards SiHa (human cervix ) cancer cell line.[3] |
Molecular Weight | 323.34 |
Formula | C19H17NO4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (69.6 mM), Sonication and heating to 61℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JB061 Cytoskeletal Signaling Myosin inhibitor inhibit