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Anti-Phospho-PTEN (Ser370) Polyclonal Antibody
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Catalog No. TMAC-03461
Alias TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser370). Anti-Phospho-PTEN (Ser370) Polyclonal Antibody can be used in WB,IHC,IF.
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody
😃Good
Catalog No. TMAC-03461Alias TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser370). Anti-Phospho-PTEN (Ser370) Polyclonal Antibody can be used in WB,IHC,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $217 | 7-10 days | |
| 100 μL | $316 | 7-10 days |
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| Description | Anti-Phospho-PTEN (Ser370) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser370). Anti-Phospho-PTEN (Ser370) Polyclonal Antibody can be used in WB,IHC,IF. |
| Synonyms | TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from HeLa cells using PTEN (phospho-Ser370) antibody (TMAC-03461). 2. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using PTEN (phospho-Ser370) antibody (TMAC-03461). 3. Immunofluorescence staining of methanol-fixed MCF7 cells using PTEN (phospho-Ser370) antibody (TMAC-03461, Red). |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 370(D-V-S(p)-D-N) derived from Human PTEN |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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