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SID 26681509

Name: SID 26681509
Brand: TargetMol
SKU: T12909
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12909Cas No. 958772-66-2

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

SID 26681509

🥰Excellent

Purity: 98.16%

Catalog No. T12909Cas No. 958772-66-2

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$459	In Stock
50 mg	$687	In Stock
100 mg	$979	In Stock
1 mL x 10 mM (in DMSO)	$175	In Stock

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Purity:98.16%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
Targets&IC50	P. falciparum:15.4 μM , Cathepsin L (human):56 nM , Leishmania major:12.5 μM
In vitro	After a 4-hour preincubation with cathepsin L, SID 26681509 becomes more potent (IC50: 1.0 nM). SID 26681509 acts as a slow-binding, slowly reversible competitive inhibitor with inhibition rate constants kon = 24,000 M^-1s^-1 and koff = 2.2 × 10^-5 s^-1 (Ki = 0.89 nM), as determined through transient kinetic analysis for single-step reversibility. Molecular docking studies, using the X-ray crystal structure of papain/CLIK-148[1], show that SID 26681509 inhibits papain and cathepsins B, K, S, and V with IC50 values ranging from 618 nM to 8.442 μM after one hour[1].
In vivo	survival in murine models of sepsis significantly improved SID 26681509 by and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2].

Chemical Properties

Molecular Weight	539.65
Formula	C₂₇H₃₃N₅O₅S
Cas No.	958772-66-2
Smiles	CCc1ccccc1NC(=O)CSC(=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Relative Density.	1.298 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/ml (101.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8531 mL	9.2653 mL	18.5305 mL	92.6526 mL
5 mM	0.3706 mL	1.8531 mL	3.7061 mL	18.5305 mL
10 mM	0.1853 mL	0.9265 mL	1.8531 mL	9.2653 mL
20 mM	0.0927 mL	0.4633 mL	0.9265 mL	4.6326 mL
50 mM	0.0371 mL	0.1853 mL	0.3706 mL	1.8531 mL
100 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9265 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc