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SID 26681509

Name: SID 26681509
Brand: TargetMol
SKU: T12909
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12909 Copy Product Info

Purity: 99.18%

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SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

SID 26681509

Copy Product Info

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Catalog No. T12909

SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).

Cas No. 958772-66-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$60	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$459	In Stock	In Stock
50 mg	$687	In Stock	In Stock
100 mg	$979	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$175	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.18%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
Targets&IC50	P. falciparum:15.4 μM , Leishmania major:12.5 μM , Cathepsin L (human):56 nM
In vitro	After a 4-hour preincubation with cathepsin L, SID 26681509 becomes more potent (IC50: 1.0 nM). SID 26681509 acts as a slow-binding, slowly reversible competitive inhibitor with inhibition rate constants kon = 24,000 M^-1s^-1 and koff = 2.2 × 10^-5 s^-1 (Ki = 0.89 nM), as determined through transient kinetic analysis for single-step reversibility. Molecular docking studies, using the X-ray crystal structure of papain/CLIK-148[1], show that SID 26681509 inhibits papain and cathepsins B, K, S, and V with IC50 values ranging from 618 nM to 8.442 μM after one hour[1].
In vivo	survival in murine models of sepsis significantly improved SID 26681509 by and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2].

Chemical Properties

Molecular Weight	539.65
Formula	C₂₇H₃₃N₅O₅S
Cas No.	958772-66-2
Smiles	CCc1ccccc1NC(=O)CSC(=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Relative Density.	1.298 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (101.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8531 mL	9.2653 mL	18.5305 mL	92.6526 mL
5 mM	0.3706 mL	1.8531 mL	3.7061 mL	18.5305 mL
10 mM	0.1853 mL	0.9265 mL	1.8531 mL	9.2653 mL
20 mM	0.0927 mL	0.4633 mL	0.9265 mL	4.6326 mL
50 mM	0.0371 mL	0.1853 mL	0.3706 mL	1.8531 mL
100 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9265 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

SID 26681509

SID 26681509

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In Vivo Formulation Calculator (Clear solution)

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