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BMS-193885

🥰Excellent

Catalog No. T14671Cas No. 186185-03-5

BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.

BMS-193885

🥰Excellent

Purity: 99.73%

Catalog No. T14671Cas No. 186185-03-5

BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.

Pack Size	Price	Availability
1 mg	$29	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$238	In Stock
50 mg	$353	In Stock
100 mg	$515	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock

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Batch Information

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Purity:99.73%

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COA LCMS

Product Introduction

Bioactivity

Description	BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.
Targets&IC50	NPY1 receptor:（ki）3.3 nM, Y1 receptor (human):5.9 nM(ki)

Chemical Properties

Molecular Weight	590.71
Formula	C₃₃H₄₂N₄O₆
Cas No.	186185-03-5
Smiles	COC(=O)C1=C(C)NC(C)=C(C1c1cccc(NC(=O)NCCCN2CCC(CC2)c2cccc(OC)c2)c1)C(=O)OC
Relative Density.	1.188 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (152.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6929 mL	8.4644 mL	16.9288 mL	84.6439 mL
5 mM	0.3386 mL	1.6929 mL	3.3858 mL	16.9288 mL
10 mM	0.1693 mL	0.8464 mL	1.6929 mL	8.4644 mL
20 mM	0.0846 mL	0.4232 mL	0.8464 mL	4.2322 mL
50 mM	0.0339 mL	0.1693 mL	0.3386 mL	1.6929 mL
100 mM	0.0169 mL	0.0846 mL	0.1693 mL	0.8464 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc