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Rineterkib

Name: Rineterkib
Brand: TargetMol
SKU: T11224
Price: 91 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11224Cas No. 1715025-32-3

Alias ERK-IN-1

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Rineterkib

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Purity: 99.73%

Catalog No. T11224Alias ERK-IN-1Cas No. 1715025-32-3

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Pack Size	Price	Availability
1 mg	$91	In Stock
5 mg	$188	In Stock
10 mg	$353	In Stock
25 mg	$598	In Stock
50 mg	$851	In Stock
100 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$248	In Stock

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Batch Information

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
In vivo	ERK-IN-1 (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.
Synonyms	ERK-IN-1

Chemical Properties

Molecular Weight	578.42
Formula	C₂₆H₂₇BrF₃N₅O₂
Cas No.	1715025-32-3
Smiles	CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)[C@@H](F)C1)c1cc(F)cc(Br)c1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/ml (103.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7288 mL	8.6442 mL	17.2885 mL	86.4424 mL
5 mM	0.3458 mL	1.7288 mL	3.4577 mL	17.2885 mL
10 mM	0.1729 mL	0.8644 mL	1.7288 mL	8.6442 mL
20 mM	0.0864 mL	0.4322 mL	0.8644 mL	4.3221 mL
50 mM	0.0346 mL	0.1729 mL	0.3458 mL	1.7288 mL
100 mM	0.0173 mL	0.0864 mL	0.1729 mL	0.8644 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc