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Dasminapant

Name: Dasminapant
Brand: TargetMol
SKU: T30095
Price: 538 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30095Cas No. 1570231-89-8

Alias SM-1387, SM1387, SM 1387, APG-1387, APG1387

Dasminapant (SM-1387) is an inhibitor of apoptosis proteins antagonist that promotes rapid degradation of cIAP1/2 and XIAP, exhibiting pronounced antitumor effects against nasopharyngeal carcinoma stem cells and synergistically enhancing chemosensitivity and apoptosis when combined with cisplatin and 5-fluorouracil in both in vitro and in vivo models.

Dasminapant

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Catalog No. T30095Alias SM-1387, SM1387, SM 1387, APG-1387, APG1387Cas No. 1570231-89-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$538	-	In Stock
5 mg	$1,330	-	In Stock
10 mg	$2,150	-	In Stock
25 mg	$3,990	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Dasminapant (SM-1387) is an inhibitor of apoptosis proteins antagonist that promotes rapid degradation of cIAP1/2 and XIAP, exhibiting pronounced antitumor effects against nasopharyngeal carcinoma stem cells and synergistically enhancing chemosensitivity and apoptosis when combined with cisplatin and 5-fluorouracil in both in vitro and in vivo models.
Synonyms	SM-1387, SM1387, SM 1387, APG-1387, APG1387

Chemical Properties

Molecular Weight	1157.41
Formula	C₆₀H₇₂N₁₀O₁₀S₂
Cas No.	1570231-89-8
Smiles	C(NC(C1=CC=CC=C1)C2=CC=CC=C2)(=O)[C@H]3N4[C@](CC3)(CCN(S(=O)(=O)C5=CC(S(=O)(=O)N6C[C@H](NC([C@@H](NC)C)=O)C(=O)N7[C@@](CC6)(CC[C@H]7C(NC(C8=CC=CC=C8)C9=CC=CC=C9)=O)[H])=CC=C5)C[C@H](NC([C@@H](NC)C)=O)C4=O)[H]
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (34.56 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8640 mL	4.3200 mL	8.6400 mL	43.1999 mL
5 mM	0.1728 mL	0.8640 mL	1.7280 mL	8.6400 mL
10 mM	0.0864 mL	0.4320 mL	0.8640 mL	4.3200 mL
20 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc