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Methyllycaconitine citrate

Name: Methyllycaconitine citrate
Brand: TargetMol
SKU: T12017
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12017Cas No. 351344-10-0

Alias MLA

Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.

Methyllycaconitine citrate

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Purity: 99.43%

Catalog No. T12017Alias MLACas No. 351344-10-0

Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$49	-	In Stock
5 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
In vitro	Pretreatment with 5 and 10 µM Methyllycaconitine citrate inhibited the decreased cell viability induced by Aβ25–35, which suggested that Methyllycaconitine citrate had a protective effect against Aβ-induced cytotoxicity. Furthermore, cell viability did not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 uM), which suggests a good safety profile[1].
In vivo	The effect of MLA on acute METH-induced effects and neurotoxicity in mice was tested using an in vivo model. The results indicate that MLA (6 mg/kg) inhibited 50% of the METH-induced climbing behavior[2].
Synonyms	MLA

Chemical Properties

Molecular Weight	874.92
Formula	C₄₃H₅₈N₂O₁₇
Cas No.	351344-10-0
Smiles	OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)C1(O)[C@@H](OC)[C@@]2([H])C33C1N(CC)C[C@]2(COC(=O)c1ccccc1N1C(=O)C[C@H](C)C1=O)CC[C@@H]3OC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (114.3 mM), Sonication is recommended.

H2O: 1 mg/mL (1.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1430 mL	5.7148 mL	11.4296 mL	57.1481 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2286 mL	1.1430 mL	2.2859 mL	11.4296 mL
10 mM	0.1143 mL	0.5715 mL	1.1430 mL	5.7148 mL
20 mM	0.0571 mL	0.2857 mL	0.5715 mL	2.8574 mL
50 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1430 mL
100 mM	0.0114 mL	0.0571 mL	0.1143 mL	0.5715 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc