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Vedaprofen

Name: Vedaprofen
Brand: TargetMol
SKU: T36683
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36683Cas No. 71109-09-6

Alias Quadrisol, PM 150, CERM 10202

Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.

Vedaprofen

🥰Excellent

Purity: 99.70%

Catalog No. T36683Alias Quadrisol, PM 150, CERM 10202Cas No. 71109-09-6

Pack Size	Price	Availability
1 mg	$49	In Stock
5 mg	$67	In Stock
10 mg	$118	In Stock
25 mg	$238	In Stock
50 mg	$353	In Stock
100 mg	$495	In Stock
1 mL x 10 mM (in DMSO)	$101	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.70%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.
In vitro	Vedaprofen blocks the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair[1]. Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9 ng/mL and 630 ng/mL, respectively[3].
In vivo	In beagle dogs, the absorption of Vedaprofen (0.5 mg/kg; oral) was rapid (tmax 0.63 h) and almost complete (bioavailability 86%). The terminal half-lives after intravenous and oral administration, 16.8 and 12.7 h respectively, were of the same order of magnitude. Vedaprofen does not accumulate in plasma[2].
Synonyms	Quadrisol, PM 150, CERM 10202

Chemical Properties

Molecular Weight	282.38
Formula	C₁₉H₂₂O₂
Cas No.	71109-09-6
Smiles	CC(C(O)=O)c1ccc(C2CCCCC2)c2ccccc12
Relative Density.	1.132 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 10 mg/mL (35.41 mM), Sonication is recommended.

DMF: 25 mg/mL (88.53 mM), Sonication is recommended.

DMSO: 50 mg/mL (177.07 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5413 mL	17.7066 mL	35.4133 mL	177.0664 mL
5 mM	0.7083 mL	3.5413 mL	7.0827 mL	35.4133 mL
10 mM	0.3541 mL	1.7707 mL	3.5413 mL	17.7066 mL
20 mM	0.1771 mL	0.8853 mL	1.7707 mL	8.8533 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0708 mL	0.3541 mL	0.7083 mL	3.5413 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0354 mL	0.1771 mL	0.3541 mL	1.7707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc