Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 216.00 |
Description | Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM. |
In vitro | Vedaprofen blocks the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair[1]. Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9 ng/mL and 630 ng/mL, respectively[3]. |
In vivo | In beagle dogs, the absorption of Vedaprofen (0.5 mg/kg; oral) was rapid (tmax 0.63 h) and almost complete (bioavailability 86%). The terminal half-lives after intravenous and oral administration, 16.8 and 12.7 h respectively, were of the same order of magnitude. Vedaprofen does not accumulate in plasma[2]. |
Synonyms | Quadrisol, PM 150, CERM 10202 |
Molecular Weight | 282.38 |
Formula | C19H22O2 |
CAS No. | 71109-09-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/ml
DMF: 25 mg/ml
DMSO: 50 mg/mL (177.07 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Vedaprofen 71109-09-6 GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience COX Prostaglandin Receptor Antibacterial Quadrisol Inhibitor nonsteroidal Escherichia coli PM-150 inhibit PM 150 PM150 serum TxB2 sliding clamp anti-inflammatory drug CERM10202 E. coli CERM-10202 COX-1 selective exudate PGE2 Cyclooxygenase CERM 10202 NSAID inhibitor