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4-Methylhistamine hydrochloride

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Catalog No. T50049Cas No. 84103-51-5

4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis.

4-Methylhistamine hydrochloride

4-Methylhistamine hydrochloride

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Purity: 95%
Catalog No. T50049Cas No. 84103-51-5
4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$68In StockIn Stock
2 mg$97In StockIn Stock
5 mg$158In StockIn Stock
10 mg$237In StockIn Stock
25 mg$398In StockIn Stock
50 mg$598In StockIn Stock
100 mg$853In StockIn Stock
500 mg$1,730InquiryInquiry
1 mL x 10 mM (in DMSO)$128In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:95%
Appearance:Solid
Color:Yellow
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COA HNMR

Product Introduction

4-Methylhistamine hydrochloride AI Summary
4-Methylhistamine hydrochloride exhibits a multifaceted bioactivity profile. It demonstrates in vivo agonist activity at the histamine H2 receptor in rats, effectively stimulating gastric acid secretion. In vitro, it acts as an agonist at the histamine H1 receptor in guinea pig ileum, albeit to a much lower extent. Cell viability assays indicate that 4-Methylhistamine hydrochloride promotes positive growth rates in HEK293T cells, human fibroblasts, and some U2OS cells, but negatively affects growth rates in other U2OS cell assays, suggesting cell type-dependent bioactivity. Thermal stability assays reveal that the compound has varying effects on the melting temperatures of different protein domains, decreasing TM in some by up to -2.22 degrees Celsius and increasing it by up to 1.12 degrees Celsius in others. Additionally, GPCR beta-arrestin recruitment assays show that 4-Methylhistamine hydrochloride exerts inhibitory effects on several targets including ADGRF1, FFAR4, and ADRB2, with inhibition ranging from -36.82% to -0.04%, while also stimulating targets such as CX3CR1 and GPR119, with maximum stimulation reaching up to 27.94%. Furthermore, the compound has been characterized using thin layer chromatography, demonstrating specific retardation factors using different solvent systems. This diverse bioactivity suggests that 4-Methylhistamine hydrochloride has complex pharmacological properties and interacts differentially across various biological targets and conditions..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis.
Chemical Properties
Molecular Weight161.633
FormulaC6H12ClN3
Cas No.84103-51-5
SmilesCl.CC1=C(CCN)NC=N1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (340.28 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.1869 mL30.9343 mL61.8686 mL309.3428 mL
5 mM1.2374 mL6.1869 mL12.3737 mL61.8686 mL
10 mM0.6187 mL3.0934 mL6.1869 mL30.9343 mL
20 mM0.3093 mL1.5467 mL3.0934 mL15.4671 mL
50 mM0.1237 mL0.6187 mL1.2374 mL6.1869 mL
100 mM0.0619 mL0.3093 mL0.6187 mL3.0934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

4-Methylhistamine Hydrochloride2(5methyl1Himidazol4yl)ethan1amine hydrochloride2 (5 methyl 1H imidazol 4 yl)ethan 1 amine hydrochloride
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