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Rosmantuzumab

Catalog No. T77750 CAS 1684393-04-1

Synonyms: OMP-131R10

Rosmantuzumab (OMP-131R10) is a humanized monoclonal antibody against R-spondin 3 (RSPO3). Rosmantuzumab has potential antitumor activity and can be used to study advanced relapsed refractory solid tumors.

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Rosmantuzumab

Rosmantuzumab, CAS 1684393-04-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 755.00
10 mg	In stock	$ 1,180.00
25 mg	In stock	$ 1,780.00
50 mg	In stock	$ 2,390.00
100 mg	In stock	$ 3,250.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rosmantuzumab (OMP-131R10) is a humanized monoclonal antibody against R-spondin 3 (RSPO3). Rosmantuzumab has potential antitumor activity and can be used to study advanced relapsed refractory solid tumors.
In vivo	Rosmantuzumab (25 mg/kg; intraperitoneal injection; once a week; for 4 weeks) significantly protects animals from developing liver fibrosis[1]. Rosmantuzumab (25 mg/kg; intraperitoneal injection; once every two weeks; for 6 weeks) in a bleomycin-induced pulmonary fibrosis mouse model significantly inhibits skin thickness, collagen deposition, and the number of α-SMA-positive cells[1].

Synonyms	OMP-131R10
Molecular Weight	N/A
CAS No.	1684393-04-1

Storage

store at low temperature

store at -80°C

References and Literature

1. Zhang M, et al. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rosmantuzumab 1684393-04-1 Others OMP-131R10 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.