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ML167

Name: ML167
Brand: TargetMol
SKU: T2670
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2670Cas No. 1285702-20-6

Alias NCGC00188654, CID44968231

ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.

ML167

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Purity: 99.82%

Catalog No. T2670Alias NCGC00188654, CID44968231Cas No. 1285702-20-6

ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$42	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$145	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$368	In Stock	In Stock
200 mg	$523	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
Targets&IC50	CLK1:1522 nM, DYRK1B:4420 nM, CLK2:1648 nM, CLK4:136 nM, DYRK1A:＞10000 nM, CDK3:＞10000 nM
In vivo	ML167 exhibits high cellular permeability and serves as a probe for Clk4 in Caco-2 assays.
Synonyms	NCGC00188654, CID44968231

Chemical Properties

Molecular Weight	335.36
Formula	C₁₉H₁₇N₃O₃
Cas No.	1285702-20-6
Smiles	Cc1ccc(CNc2ncnc3ccc(cc23)-c2ccc(CO)o2)o1
Relative Density.	1.335 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 11 mg/mL (32.8 mM), Sonication is recommended.

DMSO: 62 mg/mL (184.88 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9819 mL	14.9094 mL	29.8187 mL	149.0935 mL
5 mM	0.5964 mL	2.9819 mL	5.9637 mL	29.8187 mL
10 mM	0.2982 mL	1.4909 mL	2.9819 mL	14.9094 mL
20 mM	0.1491 mL	0.7455 mL	1.4909 mL	7.4547 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9819 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4909 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc