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ML167

Name: ML167
Brand: TargetMol
SKU: T2670
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2670Cas No. 1285702-20-6

Alias NCGC00188654, CID44968231

ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.

ML167

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Purity: 99.82%

Catalog No. T2670Alias NCGC00188654, CID44968231Cas No. 1285702-20-6

ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.

Pack Size	Price	Availability
2 mg	$29	In Stock
5 mg	$42	In Stock
10 mg	$68	In Stock
25 mg	$145	In Stock
50 mg	$247	In Stock
100 mg	$368	In Stock
200 mg	$523	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
Targets&IC50	CLK4:136 nM, DYRK1B:4420 nM, CDK3:＞10000 nM, CLK1:1522 nM, DYRK1A:＞10000 nM, CLK2:1648 nM
In vivo	ML167 exhibits high cellular permeability and serves as a probe for Clk4 in Caco-2 assays.
Synonyms	NCGC00188654, CID44968231

Chemical Properties

Molecular Weight	335.36
Formula	C₁₉H₁₇N₃O₃
Cas No.	1285702-20-6
Smiles	Cc1ccc(CNc2ncnc3ccc(cc23)-c2ccc(CO)o2)o1
Relative Density.	1.335 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 11 mg/mL (32.8 mM), Sonication is recommended.

DMSO: 62 mg/mL (184.88 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9819 mL	14.9094 mL	29.8187 mL	149.0935 mL
5 mM	0.5964 mL	2.9819 mL	5.9637 mL	29.8187 mL
10 mM	0.2982 mL	1.4909 mL	2.9819 mL	14.9094 mL
20 mM	0.1491 mL	0.7455 mL	1.4909 mL	7.4547 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9819 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4909 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc