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Taiwanin C

Name: Taiwanin C
Brand: TargetMol
SKU: TN6284
Rating: 4.5 (1 reviews)

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Catalog No. TN6284Cas No. 14944-34-4

Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.

Taiwanin C

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Catalog No. TN6284Cas No. 14944-34-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$1,850	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$2,200	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.
Targets&IC50	COX-2:9.31 μM, COX-1:9.31 μM
In vitro	Taiwanin C (1-60μM,24h) demonstrated a dose-dependent inhibition of cell viability specifically in T28 cells, while it had no impact on the normal N28 cells. Treatment with Taiwanin C dose-dependently suppressed the migration ability of T28 cells, as assessed by wound healing and migration assays. Additionally, Taiwanin C decreased the levels of β-catenin, as well as its downstream metastatic proteins Tbx3 and cMyc. Furthermore, Taiwanin C hindered the nuclear accumulation of β-catenin and facilitated its degradation through a pathway involving proteasomes. Moreover, Taiwanin C enhanced the activity of GSK-3β and reduced the levels of phosphorylated (p-ser9) GSK-3β, thereby inactivating the Wnt signaling pathway. In summary, Taiwanin C impeded the cell migration effects of T28 cells by activating GSK-3β, which led to enhanced protein degradation and reduced nuclear accumulation of β-catenin.[1]
In vivo	Taiwanin C (20 mg/kg/d, 30 mg/kg/d, 15d; injected) showed effective anti_x0002_tumor activity in nude mice models.[1]

Chemical Properties

Molecular Weight	348.31
Formula	C₂₀H₁₂O₆
Cas No.	14944-34-4
Smiles	O=C1OCc2cc3cc4OCOc4cc3c(c12)-c1ccc2OCOc2c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc