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N-Bis(2-hydroxypropyl)nitrosamine

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Catalog No. T19445Cas No. 53609-64-6
Alias Diisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPN

N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.

N-Bis(2-hydroxypropyl)nitrosamine
Other Forms of N-Bis(2-hydroxypropyl)nitrosamine:
DHPNTCL-01238308123-27-5
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N-Bis(2-hydroxypropyl)nitrosamine

😃Good
Catalog No. T19445Alias Diisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPNCas No. 53609-64-6
N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$44-In Stock
50 mg$53-In Stock
100 mg$83-In Stock
200 mg$119InquiryInquiry
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:≥98%
Appearance:Liquid
Color:Transparent
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COA HNMR

Product Introduction

Bioactivity
Description
N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.
In vivo
The carcinogenic activity of orally administered N-bis(2-hydroxypropyl)-nitrosamine (DHPN) in male Wistar rats was evaluated with respect to its dose. DHPN was administered at two doses, 100 ppm and 500 ppm, in the drinking water to rats for 25 to 52 weeks. Tumors developed in the lung, liver, and thyroid of rats receiving 100 ppm DHPN and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats receiving 500 ppm DHPN. The principal target organ was the lung in rats receiving either 100 or 500 ppm DHPN, indicating that the carcinogenic action of these doses of DHPN was similar to that of higher doses previously reported[2].
SynonymsDiisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPN
Chemical Properties
Molecular Weight162.19
FormulaC6H14N2O3
Cas No.53609-64-6
SmilesCC(O)CN(CC(C)O)N=O
Relative Density.1.2266 g/cm3 (Estimated)
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (616.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.1656 mL30.8280 mL61.6561 mL308.2804 mL
5 mM1.2331 mL6.1656 mL12.3312 mL61.6561 mL
10 mM0.6166 mL3.0828 mL6.1656 mL30.8280 mL
20 mM0.3083 mL1.5414 mL3.0828 mL15.4140 mL
50 mM0.1233 mL0.6166 mL1.2331 mL6.1656 mL
100 mM0.0617 mL0.3083 mL0.6166 mL3.0828 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Bis(2-hydroxypropyl)nitrosamineNBis(2hydroxypropyl)nitrosamineN Bis(2 hydroxypropyl)nitrosamineInhibitorinhibit
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