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Tazarotenic acid

Name: Tazarotenic acid
Brand: TargetMol
SKU: T7894
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7894Cas No. 118292-41-4

Alias AGN-190299

Tazarotenic acid (AGN-190299) is a retinoid prodrug which is converted to its active form

Tazarotenic acid

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Purity: 97.83%

Catalog No. T7894Alias AGN-190299Cas No. 118292-41-4

Tazarotenic acid (AGN-190299) is a retinoid prodrug which is converted to its active form

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$53	In Stock	In Stock
10 mg	$82	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$242	In Stock	In Stock
100 mg	$341	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Tazarotenic acid AI Summary

Tazarotenic acid demonstrates significant bioactivity with notable brain penetration and pharmacological potential in the central nervous system. In a C57BL/6 mouse model, it has a brain to serum concentration ratio (Kp) of 0.12 at a dose of 9.14 µmol/kg administered intraperitoneally. The compound's area under the concentration-time curve (AUC) in the mouse brain is 38.5 ng/g·hr, while in the mouse serum, the AUC is considerably higher at 314.5 ng/g·hr. Furthermore, Tazarotenic acid induces glucose-stimulated insulin secretion in rat INS-1 832/13 cells, with an EC50 value of 6.0 nM after 5 minutes of incubation, as measured by an ELISA assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tazarotenic acid (AGN-190299) is a retinoid prodrug which is converted to its active form
Synonyms	AGN-190299

Chemical Properties

Molecular Weight	323.41
Formula	C₁₉H₁₇NO₂S
Cas No.	118292-41-4
Smiles	CC1(C)CCSc2ccc(cc12)C#Cc1ccc(cn1)C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (30.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0921 mL	15.4603 mL	30.9205 mL	154.6025 mL
5 mM	0.6184 mL	3.0921 mL	6.1841 mL	30.9205 mL
10 mM	0.3092 mL	1.5460 mL	3.0921 mL	15.4603 mL
20 mM	0.1546 mL	0.7730 mL	1.5460 mL	7.7301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc