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Argireline

Name: Argireline
Brand: TargetMol
SKU: TP1253
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1253Cas No. 616204-22-9

Alias Acetyl hexapeptide-3

Argireline (Acetyl hexapeptide-3) is a peptide composed of amino acid chains that significantly inhibits Ca2+-dependent neurotransmitter (acetylcholine) release at the neuromuscular junction, exhibiting notable anti-wrinkle and anti-aging activity[1][2][3].

Argireline

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Purity: 99.65%

Catalog No. TP1253Alias Acetyl hexapeptide-3Cas No. 616204-22-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$40	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$168	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Argireline (Acetyl hexapeptide-3) is a peptide composed of amino acid chains that significantly inhibits Ca2+-dependent neurotransmitter (acetylcholine) release at the neuromuscular junction, exhibiting notable anti-wrinkle and anti-aging activity[1][2][3].
In vitro	The incubation of Argireline solution in varying concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM) for 48 hours exhibits a dose-dependent antiproliferative effect. The solution also shows similar effects on HSF cells. Argireline in low concentrations does not affect cell proliferation [2].
In vivo	Argireline was administered topically to elderly mice twice daily for six weeks, resulting in notable histological improvements in skin tissue. Specifically, the quantity of type I collagen fibers increased significantly (P < 0.01), and the amount of type III collagen fibers decreased (P < 0.05). This demonstrates Argireline's capability to enhance the histological architecture of skin tissue and restore aged skin[3].
Synonyms	Acetyl hexapeptide-3

Chemical Properties

Molecular Weight	888.99
Formula	C₃₄H₆₀N₁₄O₁₂S
Cas No.	616204-22-9
Smiles	[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCCNC(=N)N)=O)(NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(C)=O)=O)CCC(O)=O)=O)CCSC)=O)CCC(N)=O
Relative Density.	1.54 g/cm3
Sequence	N-acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2
Sequence Short	EEMQRR

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (281.22 mM)

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.1249 mL	5.6244 mL	11.2487 mL	56.2436 mL
5 mM	0.2250 mL	1.1249 mL	2.2497 mL	11.2487 mL
10 mM	0.1125 mL	0.5624 mL	1.1249 mL	5.6244 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0562 mL	0.2812 mL	0.5624 mL	2.8122 mL
50 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1249 mL
100 mM	0.0112 mL	0.0562 mL	0.1125 mL	0.5624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc