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(S,R,S)-AHPC-PEG3-NH2 hydrochloride

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Catalog No. T17922Cas No. 2097971-11-2
Alias VHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker Conjugates 1 HCl, VH032-PEG3-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 5

(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

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Purity: 99.67%
Catalog No. T17922Alias VHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker Conjugates 1 HCl, VH032-PEG3-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 5Cas No. 2097971-11-2
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$39-In Stock
10 mg$64-In Stock
25 mg$128-In Stock
50 mg$238-In Stock
100 mg$452-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.67%
Appearance:Oil
Color:Cyan
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.
SynonymsVHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker Conjugates 1 HCl, VH032-PEG3-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 5
Chemical Properties
Molecular Weight656.23
FormulaC30H46ClN5O7S
Cas No.2097971-11-2
SmilesC([C@@H](NC(COCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (68.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5239 mL7.6193 mL15.2386 mL76.1928 mL
5 mM0.3048 mL1.5239 mL3.0477 mL15.2386 mL
10 mM0.1524 mL0.7619 mL1.5239 mL7.6193 mL
20 mM0.0762 mL0.3810 mL0.7619 mL3.8096 mL
50 mM0.0305 mL0.1524 mL0.3048 mL1.5239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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