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(S,R,S)-AHPC-PEG3-NH2 hydrochloride (Alias: VHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker ...)

Name: (S,R,S)-AHPC-PEG3-NH2 hydrochloride
Brand: TargetMol
SKU: T17922
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T17922 Copy Product Info

Purity: 99.67%

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(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

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Catalog No. T17922

Alias VHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker Conjugates 1 HCl, VH032-PEG3-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 5

(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

Cas No. 2097971-11-2

Pack Size	Price	USA Stock	Global Stock
10 mg	$38	-	In Stock
25 mg	$77	-	In Stock
50 mg	$143	-	In Stock
100 mg	$271	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.67%

Appearance:Oil

Color:Cyan

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.
Synonyms	VHL Ligand-Linker Conjugates 1 hydrochloride, VHL Ligand-Linker Conjugates 1 HCl, VH032-PEG3-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 5

Chemical Properties

Molecular Weight	656.23
Formula	C₃₀H₄₆ClN₅O₇S
Cas No.	2097971-11-2
Smiles	C([C@@H](NC(COCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (68.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5239 mL	7.6193 mL	15.2386 mL	76.1928 mL
5 mM	0.3048 mL	1.5239 mL	3.0477 mL	15.2386 mL
10 mM	0.1524 mL	0.7619 mL	1.5239 mL	7.6193 mL
20 mM	0.0762 mL	0.3810 mL	0.7619 mL	3.8096 mL
50 mM	0.0305 mL	0.1524 mL	0.3048 mL	1.5239 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VHL Ligand-Linker Conjugates 1 HydrochlorideVHLVH032-PEG3-NH2 HydrochlorideE3LigaseLigandLinkerConjugateE3 Ligase Ligand-Linker ConjugateE3 Ligase LigandLinker ConjugateAHPC-PEG3-NH2 Hydrochloride

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