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SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
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500 mg | Inquiry | Backorder |
Description | SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity. |
Targets&IC50 | STAT3:9 nM (ki) |
In vitro | In MOLM-16 cells, SI-109 exerts a moderate growth inhibitory activity with IC50 of 3 μM. SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM. |
Molecular Weight | 835.79 |
Formula | C40H44F2N7O9P |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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