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Cefmetazole sodium

Name: Cefmetazole sodium
Brand: TargetMol
SKU: T1070
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1070Cas No. 56796-39-5

Alias Sodium cefmetazole

Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum activity against both gram-positive and gram-negative microorganisms. It demonstrates a high rate of efficacy in various types of infections, and to date, no severe side effects have been noted.

Cefmetazole sodium

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Purity: 99.87%

Catalog No. T1070Alias Sodium cefmetazoleCas No. 56796-39-5

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$53	In Stock	In Stock
1 g	$81	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:Yellow

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Product Introduction

Cefmetazole sodium AI Summary

Cefmetazole sodium demonstrates a variety of bioactivities, including potency as an inhibitor or enhancer in assays for SMN2 splice variant expression, proliferation of Plasmodium falciparum, endonuclease IV, Bloom's syndrome helicase, MPP8 Chromodomain interactions, histone lysine methyltransferases (G9a), polymerase iota and eta, mammalian selenoprotein thioredoxin reductase 1, TGF-b, phosphoglycerate kinase, glutaminase, cAMP-regulated guanine nucleotide exchange factor 2, AMA1-RON antimalarial drug lead development, and blocking the entry of Ebola virus. Additionally, it inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at 10 μM with 108.59% and 123.33% inhibition, respectively. In terms of antiviral activity, Cefmetazole sodium shows minimal inhibition of SARS-CoV-2 in various assays. At 10 μM, it exhibits very low activity in inhibiting the viability of SARS-CoV-2 infected Vero E6 cells, with an inhibition index of 0.04573. It inhibits SARS-CoV-2 induced cytotoxicity by -1.87% in Caco-2 cells at the same concentration after 48 hours. At 20 μM, it inhibits the SARS-CoV-2 3CL-Pro protease by 2.194%. However, it has shown negligible inhibition on SARS-CoV-2 induced cytotoxicity of Vero E6 cells at 10 μM after 48 hours, with an inhibition rate of -0.05%. This variation in activity suggests Cefmetazole sodium's potential role in modulating various biological pathways and processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum activity against both gram-positive and gram-negative microorganisms. It demonstrates a high rate of efficacy in various types of infections, and to date, no severe side effects have been noted.
Synonyms	Sodium cefmetazole

Chemical Properties

Molecular Weight	493.52
Formula	C₁₅H₁₆N₇NaO₅S₃
Cas No.	56796-39-5
Smiles	[C@]1([C@@H]2N(C1=O)C(=C(CS2)CSc1n(nnn1)C)C(=O)[O-])(NC(=O)CSCC#N)OC.[Na+]
Relative Density.	1.75 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0263 mL	10.1313 mL	20.2626 mL	101.3130 mL
5 mM	0.4053 mL	2.0263 mL	4.0525 mL	20.2626 mL
10 mM	0.2026 mL	1.0131 mL	2.0263 mL	10.1313 mL
20 mM	0.1013 mL	0.5066 mL	1.0131 mL	5.0657 mL
50 mM	0.0405 mL	0.2026 mL	0.4053 mL	2.0263 mL
100 mM	0.0203 mL	0.1013 mL	0.2026 mL	1.0131 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc