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Coramitug
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Catalog No. T9901A-1515 Copy Product Info
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Coramitug (PRX004) is a humanized IgG1 κ monoclonal antibody targeting transthyretin (TTR). This product binds specifically to non-native (misfolded or aggregated) forms of TTR without interacting with normal tetrameric TTR. Through its unique "amyloid depleter" mechanism, Coramitug induces macrophage-mediated phagocytosis to clear amyloid fibrils deposited in tissues, serving as a pharmacological tool for researching transthyretin amyloid cardiomyopathy (ATTR-CM).
Coramitug
Cas No. 2626841-92-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $278 | Inquiry | Inquiry | |
| 5 mg | $838 | Inquiry | Inquiry | |
| 10 mg | $1,330 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Coramitug (PRX004) is a humanized IgG1 κ monoclonal antibody targeting transthyretin (TTR). This product binds specifically to non-native (misfolded or aggregated) forms of TTR without interacting with normal tetrameric TTR. Through its unique "amyloid depleter" mechanism, Coramitug induces macrophage-mediated phagocytosis to clear amyloid fibrils deposited in tissues, serving as a pharmacological tool for researching transthyretin amyloid cardiomyopathy (ATTR-CM). |
| In vitro | In biochemical characterization, Coramitug exhibits high selectivity for misfolded TTR variants and aggregates; in cell-based assays, it effectively triggers Fcγ receptor-mediated phagocytosis of TTR amyloid fibrils by human macrophages, leading to the clearance of protein aggregates [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Transthyretin |
| Cas No. | 2626841-92-5 |
| Isotype | IgG1-REM |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Coramitug in vitro
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