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Niaprazine

Name: Niaprazine
Brand: TargetMol
SKU: T36949
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T36949 Copy Product Info

Purity: 99.56%

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Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.

Niaprazine

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Catalog No. T36949

Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.

Cas No. 27367-90-4

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Pack Size	Price	USA Stock	Global Stock
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$96	In Stock	In Stock
50 mg	$155	In Stock	In Stock
100 mg	$228	In Stock	In Stock
200 mg	$328	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.
Targets&IC50	5-HT2:25 nM(Ki), α1-adrenoceptor:77 nM(Ki)
In vitro	Niaprazine demonstrates a low affinity for the vesicular monoamine transporter as well as D2, α2, β, H1, and mAch receptors. Notably, the (+)stereoisomer of Niaprazine shows a significantly higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, whereas it is poorly recognized by 5-HT1A and 5-HT1B binding sites[2].
In vivo	Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 minutes post-treatment but reduces them 3-8 hours after treatment. Niaprazine also temporarily depletes rat brain noradrenaline (NA) and dopamine (DA) levels[3]. Animal Model: Male Sprague-Dawley rats (150-200 g)[3].

Chemical Properties

Molecular Weight	356.44
Formula	C₂₀H₂₅FN₄O
Cas No.	27367-90-4
Smiles	CC(CCN1CCN(CC1)c1ccc(F)cc1)NC(=O)c1cccnc1
Relative Density.	1.165 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (280.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8055 mL	14.0276 mL	28.0552 mL	140.2761 mL
5 mM	0.5611 mL	2.8055 mL	5.6110 mL	28.0552 mL
10 mM	0.2806 mL	1.4028 mL	2.8055 mL	14.0276 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0138 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8055 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4028 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc