Shopping Cart

Your shopping cart is currently empty

D-Cycloserine

Name: D-Cycloserine
Brand: TargetMol
SKU: T1589
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1589Cas No. 68-41-7

Alias RO-1-9213

D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.

D-Cycloserine

Copy Product Info

🥰Excellent

Purity: 99.01%

Catalog No. T1589Alias RO-1-9213Cas No. 68-41-7

D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$43	In Stock	In Stock
500 mg	$55	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.01%

Color:White

Resource Download

COA

Product Introduction

D-Cycloserine AI Summary

D-Cycloserine exhibits a broad spectrum of bioactivities, with notable antimicrobial, antimycobacterial, and antiviral properties. It shows strong antibacterial activity against various bacterial strains including Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from as low as 0.25 μg/mL to 128.0 μg/mL. Specifically, it is highly effective against Escherichia coli ATCC 9637 with MIC values of 0.25 μg/mL and 0.5 μg/mL. The compound also displays significant inhibitory activity against Mycobacterium tuberculosis strains, including drug-resistant isolates, with MIC50 values around 5.0 μg/mL and MIC90 values of 24,500 nM. Furthermore, D-Cycloserine demonstrates potent antiviral activity, notably against SARS-CoV-2, showing significant inhibition of virus-induced cytotoxicity in VERO-6 cells at various tested concentrations. Additionally, it exhibits moderate efficacy in inhibiting the NMDA receptor with IC50 and EC50 values in the nanomolar range. Despite some hepatotoxicity indications, the compound shows promise in medical applications, particularly for treating infections caused by antibiotic-resistant bacteria and tuberculosis strains, as well as certain viral infections like COVID-19..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.
Synonyms	RO-1-9213

Chemical Properties

Molecular Weight	102.09
Formula	C₃H₆N₂O₂
Cas No.	68-41-7
Smiles	N[C@H]1C(=O)NOC1
Relative Density.	1.278 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 6.66 mg/mL (65.24 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

Saline: 10.1 mg/mL (98.93 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	9.7953 mL	48.9764 mL	97.9528 mL	489.7639 mL
5 mM	1.9591 mL	9.7953 mL	19.5906 mL	97.9528 mL
10 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
20 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
50 mM	0.1959 mL	0.9795 mL	1.9591 mL	9.7953 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc