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Dimethoate
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Catalog No. T20137Cas No. 60-51-5
Alias Rogor, Phosphamid, Lurgo, L-395, L395, L 395
Dimethoate (L-395) is a systemic and contact insecticide for control of cattle grubs and certain other insect pests of farm animals.
Dimethoate
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Purity: 99.91%
Catalog No. T20137Alias Rogor, Phosphamid, Lurgo, L-395, L395, L 395Cas No. 60-51-5
Dimethoate (L-395) is a systemic and contact insecticide for control of cattle grubs and certain other insect pests of farm animals.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.91%
Appearance:Viscous
Color:White
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Product Introduction
Dimethoate AI Summary
Dimethoate shows a variety of bioactivities. It exhibits potency in inhibiting Tau fibril formation, aldehyde dehydrogenase 1 (ALDH1A1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), Nrf2, vitamin D receptor (VDR), glucocorticoid receptor signaling, farnesoid X receptor signaling (as a small molecule agonist), retinoid X receptor alpha signaling (as an antagonist), DNA re-replication in breast cells, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). Additionally, it inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at 10 uM substrate-inhibitor concentration, with inhibition percentages of 106.89% and 114.12%, respectively.
The compound also exhibits insecticidal activity against various pests, including different clones of Schizaphis graminum and Aphis gossypii, as well as Bactrocera oleae. It shows higher LC50 values and lower efficacy against organophosphate-resistant clones of Schizaphis graminum compared to susceptible ones. For Aphis gossypii, LC50 values range from 16.4 ugAi/ml to 625.0 ugAi/ml, with resistance factors indicating varying levels of potency. Against Bactrocera oleae, it achieves 100% mortality within 24 hours of exposure. These findings suggest that Dimethoate holds potential as an insecticide while also showing significant bioactivity against several molecular targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dimethoate (L-395) is a systemic and contact insecticide for control of cattle grubs and certain other insect pests of farm animals. |
| Synonyms | Rogor, Phosphamid, Lurgo, L-395, L395, L 395 |
| Molecular Weight | 229.26 |
| Formula | C5H12NO3PS2 |
| Cas No. | 60-51-5 |
| Smiles | CNC(=O)CSP(=S)(OC)OC |
| Relative Density. | 1.281 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (43.62 mM), Sonication and heating to 60℃ are recommended. DMSO: Soluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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