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Anti-SYNCRIP Antibody (5H246)
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Catalog No. TMAH-01152
Alias Synaptotagmin-binding, NSAP1, NS1-associated protein 1, HNRPQ, hnRNP Q, Heterogeneous nuclear ribonucleoprotein Q, GRY-RBP, Glycine- and tyrosine-rich RNA-binding protein, cytoplasmic RNA-interacting protein
Anti-SYNCRIP Antibody (5H246) is an antibody targeting SYNCRIP. Anti-SYNCRIP Antibody (5H246) can be used in ELISA, IHC, IF.
Anti-SYNCRIP Antibody (5H246)
Anti-SYNCRIP Antibody (5H246)
😃Good
Catalog No. TMAH-01152Alias Synaptotagmin-binding, NSAP1, NS1-associated protein 1, HNRPQ, hnRNP Q, Heterogeneous nuclear ribonucleoprotein Q, GRY-RBP, Glycine- and tyrosine-rich RNA-binding protein, cytoplasmic RNA-interacting protein
Anti-SYNCRIP Antibody (5H246) is an antibody targeting SYNCRIP. Anti-SYNCRIP Antibody (5H246) can be used in ELISA, IHC, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IHC, IF Reactivity: Human |
| Alias | Synaptotagmin-binding, NSAP1, NS1-associated protein 1, HNRPQ, hnRNP Q, Heterogeneous nuclear ribonucleoprotein Q, GRY-RBP, Glycine- and tyrosine-rich RNA-binding protein, cytoplasmic RNA-interacting protein |
| Ig Type | Rabbit IgG |
| Clone | 5H246 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-01152 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-01152 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 3. Immunofluorescence staining of Hela Cells with TMAH-01152 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IHC, IF |
| Recommended Dose | IHC:1:50-1:200; IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus.; [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human hnRNP Q |
| Antigen Species | Human |
| Gene ID | 10492 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Microbiology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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