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CM037

Name: CM037
Brand: TargetMol
SKU: T23903
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23903Cas No. 896795-60-1

Alias CM-037, CM 037, A-37, A37, A 37

CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate gynecologic malignancies.

CM037

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Purity: 99.77%

Catalog No. T23903Alias CM-037, CM 037, A-37, A37, A 37Cas No. 896795-60-1

CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate gynecologic malignancies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$127	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$393	In Stock	In Stock
100 mg	$576	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.77%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

CM037 AI Summary

CM037 exhibits significant bioactivity related to the inhibition of the ALDH1A1 and ALDH1A3 enzymes. Specifically, it inhibits ALDH1A1 with an IC50 value of 4600.0 nM using propionaldehyde as a substrate and competitively inhibits ALDH1A1 with a Ki value of 230.0 nM when NAD+ is used as a cofactor in the presence of acetaldehyde. Additionally, at a 20 μM concentration, it shows 20.0% inhibition of ALDH1A3 activity. In various assays, CM037 demonstrates IC50 values below 10,000 nM for ALDH1A1 inhibition, suggesting potent inhibitory action. Furthermore, it exhibits cytotoxic effects in human ovarian cancer cells with EC50 values between 3000-4000 nM, and enhances the cytotoxicity of the chemotherapy drug paclitaxel in cancer cells expressing ALDH1A1, emphasizing its potential as a therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate gynecologic malignancies.
Synonyms	CM-037, CM 037, A-37, A37, A 37

Chemical Properties

Molecular Weight	431.57
Formula	C₂₁H₂₅N₃O₃S₂
Cas No.	896795-60-1
Smiles	CCOC(=O)CSc1nc2c3ccccc3sc2c(=O)n1CCCN1CCCC1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (144.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3171 mL	11.5856 mL	23.1712 mL	115.8561 mL
5 mM	0.4634 mL	2.3171 mL	4.6342 mL	23.1712 mL
10 mM	0.2317 mL	1.1586 mL	2.3171 mL	11.5856 mL
20 mM	0.1159 mL	0.5793 mL	1.1586 mL	5.7928 mL
50 mM	0.0463 mL	0.2317 mL	0.4634 mL	2.3171 mL
100 mM	0.0232 mL	0.1159 mL	0.2317 mL	1.1586 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc