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PNU112455A hydrochloride

Name: PNU112455A hydrochloride
Brand: TargetMol
SKU: T8230
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8230Cas No. 21886-12-4

Alias PNU 112455A HCL

PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.

PNU112455A hydrochloride

🥰Excellent

Purity: 99.22%

Catalog No. T8230Alias PNU 112455A HCLCas No. 21886-12-4

PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	$192	In Stock	In Stock
50 mg	$296	In Stock	In Stock
100 mg	$483	In Stock	In Stock
500 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.22%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.
Targets&IC50	CDK5:3.2 μM (Km), CDK2:3.6 μM (Km)
Synonyms	PNU 112455A HCL

Chemical Properties

Molecular Weight	301.75
Formula	C₁₀H₁₂ClN₅O₂S
Cas No.	21886-12-4
Smiles	Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1
Relative Density.	1.532g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (414.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3140 mL	16.5700 mL	33.1400 mL	165.7001 mL
5 mM	0.6628 mL	3.3140 mL	6.6280 mL	33.1400 mL
10 mM	0.3314 mL	1.6570 mL	3.3140 mL	16.5700 mL
20 mM	0.1657 mL	0.8285 mL	1.6570 mL	8.2850 mL
50 mM	0.0663 mL	0.3314 mL	0.6628 mL	3.3140 mL
100 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc