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AS8351

Name: AS8351
Brand: TargetMol
SKU: T4100
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4100Cas No. 796-42-9

Alias NSC51355, AS-8351, AS 8351

AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.

AS8351

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Purity: 99.72%

Catalog No. T4100Alias NSC51355, AS-8351, AS 8351Cas No. 796-42-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$118	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$369	In Stock	In Stock
200 mg	$479	In Stock	In Stock
500 mg	$785	-	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

AS8351 AI Summary

AS8351 exhibits a broad spectrum of bioactivities. Notably, it shows significant antiproliferative activity against human SK-N-MC cells, with reported IC50 values ranging from 300.0 nM to 2530.0 nM across different studies. In an MTT assay conducted over 72 hours, the IC50 values commonly observed are approximately 710.0 nM and 1300.0 nM. Additionally, AS8351 inhibits iron uptake from transferrin in SK-N-MC cells, demonstrating an inhibition rate of up to 9% at 50 µM, and induces intracellular iron mobilization with an activity level of up to 44.0%. Despite its diverse activities, the compound exhibits weak inhibitory effects against HIV1 reverse transcriptase ribonuclease H, with IC50 values greater than 100,000.0 nM. AS8351 also demonstrates antimicrobial activity against various bacteria and fungi, cytotoxicity against several human cell lines, and antiviral activity against a range of viruses. Additionally, it shows bioactivity as an inhibitor of the interaction between human Flag-tagged LEDGF and His6-tagged HIV1 integrase with an IC50 of 6000.0 nM, but does not affect HIV1 integrase's strand transfer or 3'-processing activities significantly. Lastly, it exhibits antimalarial activity against Plasmodium falciparum 7G8, with an IC50 of 42.2 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
Synonyms	NSC51355, AS-8351, AS 8351

Chemical Properties

Molecular Weight	291.3
Formula	C₁₇H₁₃N₃O₂
Cas No.	796-42-9
Smiles	NN(\C=C1/C(=O)C=Cc2ccccc12)C(=O)c1ccncc1
Relative Density.	1.364g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.59 mg/mL (129.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4329 mL	17.1644 mL	34.3289 mL	171.6444 mL
5 mM	0.6866 mL	3.4329 mL	6.8658 mL	34.3289 mL
10 mM	0.3433 mL	1.7164 mL	3.4329 mL	17.1644 mL
20 mM	0.1716 mL	0.8582 mL	1.7164 mL	8.5822 mL
50 mM	0.0687 mL	0.3433 mL	0.6866 mL	3.4329 mL
100 mM	0.0343 mL	0.1716 mL	0.3433 mL	1.7164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc