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Imirestat

Name: Imirestat
Brand: TargetMol
SKU: T15568
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15568Cas No. 89391-50-4

Alias HOE 843, Alcon 1576, AL 1576

Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.

Imirestat

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Purity: 99.5%

Catalog No. T15568Alias HOE 843, Alcon 1576, AL 1576Cas No. 89391-50-4

Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$75	In Stock
25 mg	$151	In Stock
50 mg	$243	In Stock
100 mg	$389	In Stock
200 mg	$553	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Batch Information

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Purity:99.5%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.
In vivo	Administration of 1 mg/kg Imirestat increased nerve conduction velocity, however, had no effect on resistance to hypoxic conduction block or deficits in insulin-stimulated Uban-sensitive ATPase activity[1].
Synonyms	HOE 843, Alcon 1576, AL 1576

Chemical Properties

Molecular Weight	286.23
Formula	C₁₅H₈F₂N₂O₂
Cas No.	89391-50-4
Smiles	Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1
Relative Density.	1.58g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (349.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4937 mL	17.4685 mL	34.9369 mL	174.6847 mL
5 mM	0.6987 mL	3.4937 mL	6.9874 mL	34.9369 mL
10 mM	0.3494 mL	1.7468 mL	3.4937 mL	17.4685 mL
20 mM	0.1747 mL	0.8734 mL	1.7468 mL	8.7342 mL
50 mM	0.0699 mL	0.3494 mL	0.6987 mL	3.4937 mL
100 mM	0.0349 mL	0.1747 mL	0.3494 mL	1.7468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc