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Narlaprevir

Name: Narlaprevir
Brand: TargetMol
SKU: T16274
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16274Cas No. 865466-24-6

Alias SCH900518, SCH 900518

Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.

Narlaprevir

🥰Excellent

Catalog No. T16274Alias SCH900518, SCH 900518Cas No. 865466-24-6

Pack Size	Price	Availability	Quantity
2 mg	$249	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.
Targets&IC50	Replicon RNA:40 nM (EC90), NS3 protease:6 nM (Ki), Ketoamide:7 nM (Ki), NS3 protease:40 nM (EC90)
In vitro	Narlaprevir is a selective NS3 protease inhibitor with a Ki of 6 nM and an EC90 of 40 nM. Narlaprevir is also an inhibitor of SARS-CoV 3CLpro with an IC50 of 2.3 μM. [1] [2]
In vivo	Narlaprevir rats, when administered orally, showed a very good AUC of 6.5 μM·h and a bioavailability of 46%. It is well distributed in target organs. The liver concentration of rats was 750 ng/g at 8 hours (C8h) after administration. [1]
Synonyms	SCH900518, SCH 900518

Chemical Properties

Molecular Weight	707.96
Formula	C₃₆H₆₁N₅O₇S
Cas No.	865466-24-6
Smiles	C(N[C@H](C(C(NC1CC1)=O)=O)CCCC)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(NC4(CS(C(C)(C)C)(=O)=O)CCCCC4)=O)[C@](C)(C)C)=O)[H])[H]
Relative Density.	1.21 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 40 mg/mL (56.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4125 mL	7.0625 mL	14.1251 mL	70.6255 mL
5 mM	0.2825 mL	1.4125 mL	2.8250 mL	14.1251 mL
10 mM	0.1413 mL	0.7063 mL	1.4125 mL	7.0625 mL
20 mM	0.0706 mL	0.3531 mL	0.7063 mL	3.5313 mL
50 mM	0.0283 mL	0.1413 mL	0.2825 mL	1.4125 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc