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Narlaprevir

Name: Narlaprevir
Brand: TargetMol
SKU: T16274
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16274Cas No. 865466-24-6

Alias SCH900518, SCH 900518

Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.

Narlaprevir

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Catalog No. T16274Alias SCH900518, SCH 900518Cas No. 865466-24-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.
Targets&IC50	NS3 protease:40 nM (EC90), NS3 protease:6 nM (Ki), Ketoamide:7 nM (Ki), Replicon RNA:40 nM (EC90)
In vitro	Narlaprevir is a selective NS3 protease inhibitor with a Ki of 6 nM and an EC90 of 40 nM. Narlaprevir is also an inhibitor of SARS-CoV 3CLpro with an IC50 of 2.3 μM. [1] [2]
In vivo	Narlaprevir rats, when administered orally, showed a very good AUC of 6.5 μM·h and a bioavailability of 46%. It is well distributed in target organs. The liver concentration of rats was 750 ng/g at 8 hours (C8h) after administration. [1]
Synonyms	SCH900518, SCH 900518

Chemical Properties

Molecular Weight	707.96
Formula	C₃₆H₆₁N₅O₇S
Cas No.	865466-24-6
Smiles	C(N[C@H](C(C(NC1CC1)=O)=O)CCCC)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(NC4(CS(C(C)(C)C)(=O)=O)CCCCC4)=O)[C@](C)(C)C)=O)[H])[H]
Relative Density.	1.21 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 40 mg/mL (56.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4125 mL	7.0625 mL	14.1251 mL	70.6255 mL
5 mM	0.2825 mL	1.4125 mL	2.8250 mL	14.1251 mL
10 mM	0.1413 mL	0.7063 mL	1.4125 mL	7.0625 mL
20 mM	0.0706 mL	0.3531 mL	0.7063 mL	3.5313 mL
50 mM	0.0283 mL	0.1413 mL	0.2825 mL	1.4125 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc