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Anti-Beclin-1 Polyclonal Antibody 2
(Synonyms: Protein GT197, GT197, Coiled-coil myosin-like BCL2-interacting protein, BECN1, Beclin-1) Copy Product Info
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Synonyms: Protein GT197, GT197, Coiled-coil myosin-like BCL2-interacting protein, BECN1, Beclin-1
Catalog No. TMAB-00210 Copy Product Info
🥰Excellent
Anti-Beclin-1 Polyclonal Antibody 2 is a Rabbit antibody targeting Beclin-1. Anti-Beclin-1 Polyclonal Antibody 2 can be used in IF, IHC-Fr, IHC-P, WB.
Anti-Beclin-1 Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Beclin-1 Polyclonal Antibody 2 is a Rabbit antibody targeting Beclin-1. Anti-Beclin-1 Polyclonal Antibody 2 can be used in IF, IHC-Fr, IHC-P, WB. |
| Synonyms | Protein GT197, GT197, Coiled-coil myosin-like BCL2-interacting protein, BECN1, Beclin-1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Rabbit) |
| Application | |
| Recommended Dose | IF=1:100-500; IHC-Fr=1:400-800; IHC-P=1:400-800; WB=1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. |
| Immunogen | KLH conjugated synthetic peptide: human BECN1 |
| Antigen Species | Human |
| Gene Name | BECN1 |
| Gene ID | |
| Protein Name | Beclin-1 |
| Uniprot ID | |
| Biology Area | Signal Transduction,Tumor suppressors,Autophagy,Tumor Suppressors,Autophagy and mitophagy,Host Immune Response |
| Function | Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. |
| Molecular Weight | Theoretical: 60 kDa. Actual: 56 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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