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1-Thioglycerol
🥰Excellent
Catalog No. T84846Cas No. 96-27-5
Alias alpha-Thioglycerol
1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).
1-Thioglycerol
1-Thioglycerol
🥰Excellent
Purity: 99.80%
Catalog No. T84846Alias alpha-ThioglycerolCas No. 96-27-5
1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 g | $29 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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Purity:99.80%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS). |
| Targets&IC50 | Glycerol kinase (bovine adrenal):1.9 mM (Ki), Glycerol kinase (human fibroblast lysate):3.4 mM (Ki) |
| In vitro | 1-Thioglycerol shows Ki values of 1.9 mM in bovine adrenal extracts and 3.4 mM in human fibroblast lysates, acting specifically against glycerol in a competitive manner. The inhibitory effect of 1-Thioglycerol is reversible and dose-dependent[1]. In human fibroblasts, I-TG (up to 10 mM, 24 h) reduces glycerol kinase activity by ~30% without affecting protein synthesis (as measured by ³H-leucine incorporation). Higher concentrations cause cytotoxicity and cell detachment[1]. |
| Alias | alpha-Thioglycerol |
| Molecular Weight | 108.16 |
| Formula | C3H8O2S |
| Cas No. | 96-27-5 |
| Smiles | OCC(O)CS |
Storage & Solubility Information
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (739.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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