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1-Thioglycerol

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Catalog No. T84846Cas No. 96-27-5
Alias alpha-Thioglycerol

1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).

1-Thioglycerol

1-Thioglycerol

🥰Excellent
Purity: 99.80%
Catalog No. T84846Alias alpha-ThioglycerolCas No. 96-27-5
1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 g$29-In Stock
1 mL x 10 mM (in DMSO)$44-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.80%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).
Targets&IC50
Glycerol kinase (human fibroblast lysate):3.4 mM (Ki), Glycerol kinase (bovine adrenal):1.9 mM (Ki)
In vitro
1-Thioglycerol shows Ki values of 1.9 mM in bovine adrenal extracts and 3.4 mM in human fibroblast lysates, acting specifically against glycerol in a competitive manner. The inhibitory effect of 1-Thioglycerol is reversible and dose-dependent[1]. In human fibroblasts, I-TG (up to 10 mM, 24 h) reduces glycerol kinase activity by ~30% without affecting protein synthesis (as measured by ³H-leucine incorporation). Higher concentrations cause cytotoxicity and cell detachment[1].
Synonymsalpha-Thioglycerol
Chemical Properties
Molecular Weight108.16
FormulaC3H8O2S
Cas No.96-27-5
SmilesOCC(O)CS
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (739.64 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (30.51 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM9.2456 mL46.2278 mL92.4556 mL462.2781 mL
5 mM1.8491 mL9.2456 mL18.4911 mL92.4556 mL
10 mM0.9246 mL4.6228 mL9.2456 mL46.2278 mL
20 mM0.4623 mL2.3114 mL4.6228 mL23.1139 mL
50 mM0.1849 mL0.9246 mL1.8491 mL9.2456 mL
100 mM0.0925 mL0.4623 mL0.9246 mL4.6228 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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