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VEGFR-2/DHFR-IN-2

Catalog No. T61229

VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, with IC50 values ranging from 3.59 μM to 8.38 μM. VEGFR-2/DHFR-IN-2 holds promise for cancer research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

VEGFR-2/DHFR-IN-2, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

VEGFR-2/DHFR-IN-2, tested across concentrations of 2-1024 μg/mL for 18-72 hours, demonstrates significant antimicrobial activity, evident from minimum inhibitory concentration (MIC) values against various pathogens: Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, Methicillin-Sensitive Staphylococcus aureus (MSSA), Methicillin-Resistant Staphylococcus aureus (MRSA), Candida albicans, and Aspergillus niger at 64, 64, 32, 32, 16, 32, 64, and 256 μg/mL respectively. Additionally, when applied in concentrations ranging from 0.5-100 μM over 48 hours, this compound shows anticancer effects. Furthermore, its inhibition of DHFR and VEGFR-2 is confirmed through tests at 0-100 μM for 30 minutes, with IC50 values of 9.085 μM for DHFR and 0.623 μM for VEGFR-2 inhibition. Cell cytotoxicity assays conducted on C26, HepG2, MCF7, and H69PR cell lines with concentrations of 0.5-100 μM over 48 hours confirm its anticancer activity, exhibiting IC50 values of 3.59, 8.38, 6.75, and 28.45 μM, respectively.

Molecular Weight	351.4
Formula	C21H21NO4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VEGFR-2/DHFR-IN-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.